Dana-farber-cancer Institute Inc.

Lian Xu

Steven P Treon

Diagnostic assays for discriminating Waldenstrom's Macroglobulinemia from IgM monoclonal gammopathy of undetermined significance are provided. The method comprises obtaining a biological sample from a subject in need thereof, performing an allele-specific polymerase chain reaction assay to determine in the biological sample a level of a transcript comprising a mutation at position 38182641 in chromosome 3p22.2, and providing a report indicating whether delta Cvalue of the biological sample is less than a reference value, wherein the subject has Waldenstrom's Macroglobulinemia if the delta Cvalue is less than the reference value.

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Waltham, MA, United States of America

Lian Xu