Natrogen Therapeutics International, Inc.

Genentech, Inc.

Genetech, Inc.

Natrogen Therapeutics, Inc.

Lian Mo

Longgui Wang

Simon K Mencher

James P McCarron, Jr

Xiao Mei Liu

Kenneth Flanagan

Xiaomei Liu

Lauri Diehl

James P Mccarron

The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical composition comprises one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, an anti-inflammatory agent, and a pharmaceutically acceptable carrier.

Methods of treating an inflammatory-related disease

The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA in an amount less than sufficient to inhibit CDKs.

The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.

Methods for detecting inflammatory bowel disease

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Palo Alto, CA, United States of America

Lian Mo