University of Pennsylvania

Lian Lam

Mark I Greene

Hongtao Zhang

Zheng Cai

Zhiqiang Zhu

Hiromichi Tsuchiya

Yasuhiro Nagai

Aaron Runkle

Jeffrey Drebin

Mei Qing Ji

Yashuiro Nagai

Disclosed herein are methods of increasing response to radiation therapy in subjects afflicted with cancer. In some embodiments, the method comprises reducing the ability of an immune suppressor cell (e.g., MDSC) to migrate to the microenvironment of the cancer. In some embodiments, the method further comprises suppressing the migration of the immune suppressor cell to a non-malignant cell and/or suppressing the malignant transformation of the non-malignant cells.

Methods of increasing response to cancer radiation therapy

Disclosed herein are multifunctional antigen-binding proteins comprising at least one multifunctional recombinant protein scaffold and at least one antigen-specific binding domain. Polynucleotides encoding the multifunctional antigen-binding proteins, vectors containing the disclosed polynucleotides, and cells that have been genetically engineered to express the polynucleotide are also provided. Methods of using the multifunctional antigen-binding proteins are disclosed.

IgG binding peptides and multifunctional antigen-binding proteins comprising the same

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Philadelphia, PA, United States of America

Lian Lam