University of Kansas

Silvergate Pharmaceuticals Inc.

Nps Pharmaceuticals, Inc.

Silvergate Pharmacauticals, Inc.

Lian G Rajewski

John L Haslam

Roger A Rajewski

Robert Mauro

Peter Colabuono

Kathleen Heppert

Michael C Beckloff

Frank Segrave

James D Pipkin

Thomas B Marriott

Frank Seagrave

David S Wells

Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain diseases including hypertension, heart failure and asymptomatic left ventricular dysfunction.

Enalapril compositions

The present disclosure provides rapidly dissolving oral capsules and films comprising pullulan, a plasticizer, and a dissolution enhancing agent.

Rapidly dissolving pharmaceutical compositions comprising pullulan

Sustained-release compositions for delivering therapeutic concentrations of isovaleramide, isovaleric acid, and certain structurally related compounds are provided for the treatment for a variety of pathological conditions, including epilepsy and spasticity, which are ameliorated by effecting a modulation of CNS activity. The ability of the compositions to sustain relatively constant levels of the drug at a therapeutic dose in the serum for extended periods of time enables a once or twice daily administration schedule.

Sustained-release formulations for treating CNS-mediated disorders

Growing community of inventors

Lawrence, KS, United States of America

Lian G Rajewski