Coswell S.p.a.

Politecnico Di Milano

Medacta International Sa

Nextmaterials S.r.l

Lia Rimondini

Francesco Siccardi

Norberto Roveri

Michele Iafisco

Luigi De Nardo

Paolo Gualandi

Giancarlo Gazzaniga

Barbara Palazzo

Matteo Parravicini

Angelo De Lollis

Roberto Chiesa

Elena Maria Varoni

Lina Altomare

The invention relates to biologically active nanoparticles of a carbonate-substituted non-stoichiometric hydroxyapatite, having: The biologically active nanoparticles of the invention find a preferred use in oral or dental hygiene applications and may be formulated as compositions for oral or dental hygiene such as, for example, solutions, suspensions, oils, gels or other solid products. Other aspects of the invention include a process for preparing a suspension for oral or dental hygiene including the aforementioned biologically active nanoparticles, a process for manufacturing a toothpaste comprising the nanoparticles, as well as a method of locally remineralizing the teeth comprising contacting the teeth with the nanoparticles.

Biologically active nanoparticles a carbonate-substituted hydroxyapatite, process for their preparation and compositions incorporating the same

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Bologna, Italy

Lia Rimondini