University of Minnesota

University of Toronto

Smithsonian Institution

Li Zhan

John Bischof

Taner Akkin

Zhenpeng Qin

Warren Chan

Mary Hagedorn

Kanav Khosla

Nikolas Zuchowicz

Jonathan Daly

Methods and vitrification systems for biological samples are provided. The vitrification system has a rotatable cryowheel () with a facing surface (). Droplets of a composition that includes a biological sample are released onto the facing surface. Droplets are rapidly pulled beneath the surface of the cryogenic coolant () to generate vitrified samples (). Methods and cryopreservation devices are also provided that incorporate the vitrification systems.

High throughput system for production and vitrification of biomaterials in cryoprotectant droplets

Assays used in conjunction with a thermal contrast reader are disclosed. In the assay, the test strip includes materials that can develop a thermal response if a target analyte is present in a sample. Linear flow assays include nanoparticles with high affinity binding to the analyte. Binding of the nanoparticles with an analyte in the sample is detected using thermal contrast. Analytes over a broad range of concentrations are detected in the linear flow assays. Methods of detecting target analytes and kits comprising lateral flow assays and thermal contrast reader are also disclosed.

Lateral flow assays with thermal contrast readers

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Minneapolis, MN, United States of America

Li Zhan