Huawei Technologies Co., Limited

Beijing Yisheng Biotechnology Co., Ltd.

Other

Li Zha

Fang Liu

Haixiang Lin

Guilin Sun

Xianyin Xin

Huaizhong Liu

Xiaolin Sun

A novel composite, and research on the preparation, application and the like of the composite. The method for preparing the composite comprises: contacting a polyinosinic-polycytidylic acid, at least one cationic stabilizer, and a soluble calcium salt in a liquid reaction system, the cationic stabilizer being a water-soluble non-antibiotic amino compound having a molecular weight of less than or equal to 5 kDa, or a graft copolymer formed by a water-soluble non-antibiotic amino compound and one or more of methoxypolyethylene glycol, polyethylene glycol, polyethylenimine, folic acid, or galactose. The composite has moderate viscosity and molecular weight, is convenient to use in pharmaceutical application, has stable chemical properties, is not easy to be degraded in long-term storage, and is safe to use. The composite, if used alone, can significantly enhance the non-specific immune response of the body and achieve the purpose of preventing and treating diseases, and other drugs, and can achieve better anti-tumor, anti-viral and anti-(super) bacteria efficacy and is easily absorbed by patients, if used in combination with other drugs.

Methods for preparing complex for enhancing immune response

Complex for enhancing immune response

The present invention relates to an anti-infection and anti-tumor mucosal immune preparation. The mucosal immune preparation includes mucosal immune substances that are mainly formed by organically bonding polyinosinic-polycytidylic acid, non-antibiotic amino compounds and metal cations through chemical bonds. The present invention provides a slow release effect on a local part or the whole body, prevents the degradation of serum ribonucleases of human beings and primates, prolong the half-life period of the mucosal immune preparation, increases the availability and effectiveness of drugs. The mucosal immune preparation can facilitate the mucosal immunity of the body by mucosal immunity and thus facilitate the activation and proliferation of various immune cells, rather than merely acting on diseased local parts, so that the purposes of anti-infection and anti-tumor prevention and treatment with almost no side effects are realized. Mucosal immunity also avoids the pain of repeated injection so that good compliance is achieved.

Anti-infection and anti-tumor mucosal immune preparation

A method and apparatus with a data storage device receives a data write request that is sent by a first tenant, and determines, from a plurality of resource zones (RZs) and based on the data write request and storage permission of the first tenant for each of the plurality of RZs. The data storage device further determines distribution of N duplicates in the at least one RZ based on the data write request and a first data distribution policy, and stores the N duplicates into at least one node corresponding to the at least one RZ based on distribution of the N duplicates in the at least one RZ and a second data distribution policy.

Data storage method and apparatus for combining different data distribution policies

A method and apparatus for data storage and retrieval is disclosed. In the method, a data storage device receives a data write request that is sent by a first tenant, and determines, from a plurality of resource zones (RZs) and based on the data write request and storage permission of the first tenant for each of the plurality of resource zones RZs. The data storage device further determines distribution of N duplicates in the at least one RZ based on the data write request and a first data distribution policy, and stores the N duplicates into at least one node corresponding to the at least one RZ based on distribution of the N duplicates in the at least one RZ and a second data distribution policy.

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Beijing, China

Li Zha