Sichuan University

Venus Medtech (Hangzhou) Inc.

Chengdu University of Information Technology

Southwest Petroleum University

Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.

Shanxi Jinbo Bio-Pharmaceutical Co., Ltd.

Sichuan Animal Science Academy

Venus Medtech, Inc.

Cspc Zhongqi Pharmaceutical Technology Co., Ltd.

Li Yang

Yunbing Wang

Qiang Yang

Hou-Sen Lim

Jun Liu

Dajun Kuang

Jincheng Yu

Jiawei Wang

Gexiang Zhang

Qiyu Liu

Minyao Tan

Dapeng Zhang

Xiaozhao Jin

Zhenyu Wang

Xingdong Zhang

Rifang Luo

Gaocan Li

Yang Lei

Ming Zhu

Yuquan Wei

Xia Yang

Lu Lu

Xiang Chen

Junlin Liu

Hou Sen Lim

Xiaosong Jiang

Gaoyang Guo

Qin Qin

Chaowu Yang

Mohan Qiu

Zengrong Zhang

Chunlin Yu

Huarui Du

Qingyun Li

Bo Xia

Xiaoyan Song

Chenming Hu

Xia Xiong

Han Peng

Xiaohong He

Jialei Chen

Ke Men

Xueyan Zhang

An anti-thrombotic and endothelialization-enhanced bioprosthetic valve material and preparation thereof are provided. The preparation method includes the following steps: immersing a glutaraldehyde cross-linked bioprosthetic valve material in functional reagent solution for 1-24 h, adjusting pH value of the solution to 3-8, removing it from solution and cleaning with deionized water. The new valve material of the present invention can effectively reduce the toxicity and side effects of the existing glutaraldehyde cross-linked bioprosthetic valve material and effectively reduce thrombosis, along with enhanced endothelialization. The material prepared can be used for pulmonary valve, aortic valve, mitral valve, tricuspid valve, venous valve and other cardiovascular implantable medical devices.

Anti-thrombotic and endothelialization-enhanced bioprosthetic valve material and preparation method thereof

A method for preparing a pre-loadable biological heart valve capable of rapid rehydration includes performing a cross-linking treatment, wherein a biological valve is cross-linked by soaking in an aqueous glutaraldehyde solution; performing a hydrophilic treatment, wherein the biological valve is soaked in a solution containing a hydrophilic molecule and a condensing agent, to allow the hydrophilic molecule to be immobilized on the biological valve by chemical grafting; and performing a drying treatment, wherein the biological valve after the hydrophilic treatment and the cross-linking treatment is dried to obtain the pre-loadable biological heart valve capable of rapid rehydration.

Pre-loadable biological heart valve capable of rapid rehydration and preparation method thereof

A bioprosthetic valve and a preparation method thereof are provided. The bioprosthetic valve includes a stent and a functional biological tissue material attached to the stent. The functional biological tissue material is a biologicaltissue covalently bonded with an active group and a functional molecule or group. The method improves the anti-thrombosis and anti-calcification functions by covalently modifying the surface of a biological valve using an active group and a functional molecule or group with a substantial degree of grafting. The new bioprosthetic valve does not include aldehyde residues, exhibits excellent biocompatibility, optimal mechanical properties, high stability, and can meet the performance requirements of a biological valve delivered through a catheter.

Bioprosthetic valve and preparation method thereof

A recognition method for safety behaviors in an industrial control system for a gas field and a recognition system thereof are provided. The recognition method includes: S, collecting sample data of the industrial control system, and obtaining an analysis report based on the sample data; S, generating a critical application programming interface (API) call dependency graph and a resource dependency graph based on the analysis report; S, converting the critical API call dependency graph and the resource dependency graph into numerical matrixes; S, constructing a detection model according to the numerical matrixes, and then detecting a program abnormal behavior of an industrial control host program based on the detection model, to obtain a recognition result, and the recognition result is a normal behavior or an abnormal behavior. The recognition method and system address issues such as high resource occupancy, timeliness, and inaccuracy in safety behavior recognition for industrial control system.

Recognition method and system for safety behaviors in industrial control system for gas field

A pre-loadable dried biological heart valve and a preparation method thereof. The preparation method includes: Step A: soaking a fresh animal pericardium in an aqueous solution of soluble elastin or glycosaminoglycan, and then subjecting the pericardium to a first cross-linking reaction in a mixed solution of carbodiimide or N-hydroxysuccinimide to allow the soluble elastin or glycosaminoglycan to bind to the pericardium via a chemical bond; and Step B: subjecting the pericardium after the first cross-linking to a second cross-linking reaction in an aqueous glutaraldehyde solution, and then drying the pericardium after the second cross-linking, to obtain the pre-loadable dried biological heart valve. The dried biological heart valve obtained by the above preparation method has good toughness, and is rapidly flattened out in a simulated folding and pressing test.

Pre-loadable dried biological heart valve and preparation method thereof

An apparatus for dismounting and mounting a high-voltage line T-connector in a hot-line operation includes a lifting platform, a four-axis platform and an end-effector mechanism; the four-axis platform and the end-effector mechanism are both electrically conductive structures; the four-axis platform is fixedly mounted on the top of the lifting platform, and an insulating layer is provided between the four-axis platform and the lifting platform; the four-axis platform is movable in the X direction, the Y direction, and the Z direction, and is rotatable around the Z direction; the four-axis platform is provided with an equipotential mechanism; the end-effector mechanism is detachably fastened to the four-axis platform; and a bolt loosening/tightening mechanism or a nut cutting device capable of moving in the X direction, the Y direction, and the Z direction is provided on the end-effector mechanism.

Apparatus for dismounting and mounting high-voltage line T-connector in hot-line operation

A recombinant human collagen-based multifunctional stent coating and a preparation method thereof are provided. The preparation method includes (1) activating a substrate material; (2) placing the activated substrate material in an amino compound-containing solution for a reaction to obtain an aminated substrate material; (3) placing the aminated substrate material in a polyanion electrolyte solution for a reaction, and cleaning with deionized water. The recombinant human collagen-based multifunctional stent coating prepared by the present invention effectively improves the anticoagulation and rapid endothelialization performance of biomaterials, such as vascular stent materials, and reduces the late thrombosis and restenosis problems existing in current stent materials.

Recombinant human collagen-based multifunctional stent coating and preparation method thereof

A sea creature cleaning robot for an intake tunnel for a nuclear power plant includes a frame, cutter assemblies, and walking wheel assemblies; the frame is used for mounting and fixing cutter mounting seats and crawler wheels; the walking wheel assemblies mounted on the frame enable the entire device to normally walk in a tunnel; the cutter assemblies control the height of cutters by means of hydraulic cylinders to make the cutters contact the inner wall of the tunnel, and the hydraulic cylinders drive the saw-toothed cutters to move back and forth to remove sea creatures attached to the inner wall of the tunnel; the cutter assemblies are uniformly distributed on the frame, so as to ensure full coverage of the cleaning range of the cross section of the tunnel. The robot can clean sea creatures in tunnels in place of manual work to significantly improve the cleaning efficiency.

Sea creature cleaning robot for intake tunnel for nuclear power plant

A breeding method for improving reproductive performance of a chicken specialized dam line includes the steps of forming an F1 generation group, forming a breeding group, screening a breeding group, forming an F2 generation group, and continuously breeding to an Fn generation group. The method includes raising in small-scale groups and natural mating for systematic selection and breeding, which effectively reduces the generation interval and has the features of easy operation and fast genetic progress, not only ensuring animal welfare, but also effectively improving production performance.

Breeding method for improving reproductive performance of chicken specialized dam line

The present invention relates to the field of genetic engineering drugs, particularly to a novel B cell activating factor (BAFF) antagonist and use thereof. The technical problem to be solved by the invention is to find a new and effective selection for the prevention and treatment of autoimmune diseases. The B cell activating factor receptor antagonist is mainly obtained by the fusion of the domain 2 binding BAFF in TACI receptor and the domain binding BAFF in Br3 receptor, and it also can be fused with a Fc segment of IgG1 to obtain a new fusion protein molecule. Experiments indicate that said new fusion protein molecule has the function of BAFF antagonist, which can treat the autoimmune diseases, and supply a new and effective selection for the prevention and treatment of the autoimmune diseases.

B cell activating factor antagonist and preparation method and use thereof

Growing community of inventors

Chengdu, China

Li Yang