I2 Pharmaceuticals, Inc.

Altravax, Inc.

Sea Lane Biotechnologies, LLC

Viiv Healthcare UK Limited

Li Xu

Ramesh Bhatt

Lawrence C Horowitz

Nicholas A Meanwell

Sing-Yuen Sit

Yan Chen

Jie Chen

Alicia Regueiro-Ren

Ny Sin

Jacob Swidorski

Richard A Hartz

Zheng Liu

Brian Lee Venables

Robert Gerald Whalen

Charles H Hannum

Arun K Kashyap

Michael D Horowitz

Aaron L Kurtzman

Ryann E O'Neil

Clayton W Beard

Hakima Sbai

Ramesh R Bhatt

Medini Gore

Phil Kobel

Sihong Zhou

Lawrence Horowitz

Ryann E O' Neil

Alicia Regueiro-ren

Danying Cai

Pamela Foreman

Michael Horowitz

The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same.

Constructs and libraries comprising antibody surrogate light chain sequences

Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to DR4 and/or DR5 and aspects relating to such constructs and their use.

Surrogate binding proteins which bind DR4 and/or DR5

This document provides methods and materials for producing immune responses against hepatitis B viruses. For example, polypeptides, nucleic acid molecules encoding such polypeptides, virus-like particles containing such polypeptides, vaccine preparations containing one or more polypeptides provided herein, vaccine preparations containing one or more nucleic acid molecules provided herein, vaccine preparations containing one or more virus-like particles provided herein, and methods for inducing immune responses against hepatitis B viruses within mammals (e.g., humans) are provided.

Hepatitis B virus vaccines

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Cupertino, CA, United States of America

Li Xu