I2 Pharmaceuticals, Inc.

Altravax, Inc.

Sea Lane Biotechnologies, LLC

Viiv Healthcare UK Limited

Li Xu

Nicholas A Meanwell

Sing-Yuen Sit

Jie Chen

Alicia Regueiro-Ren

Ny Sin

Zheng Liu

Ramesh Bhatt

Lawrence C Horowitz

Robert Gerald Whalen

Charles H Hannum

Michael D Horowitz

Arun K Kashyap

Aaron L Kurtzman

Ryann E O'Neil

Medini Gore

Clayton W Beard

Hakima Sbai

Sihong Zhou

Phil Kobel

Alicia Regueiro-ren

Danying Cai

Yan Chen

Pamela Foreman

Michael Horowitz

Lawrence Horowitz

Ryann E O' Neil

The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same.

Constructs and libraries comprising antibody surrogate light chain sequences

Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to DR4 and/or DR5 and aspects relating to such constructs and their use.

Surrogate binding proteins which bind DR4 and/or DR5

This document provides methods and materials for producing immune responses against hepatitis B viruses. For example, polypeptides, nucleic acid molecules encoding such polypeptides, virus-like particles containing such polypeptides, vaccine preparations containing one or more polypeptides provided herein, vaccine preparations containing one or more nucleic acid molecules provided herein, vaccine preparations containing one or more virus-like particles provided herein, and methods for inducing immune responses against hepatitis B viruses within mammals (e.g., humans) are provided.

Hepatitis B virus vaccines

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Cupertino, CA, United States of America

Li Xu