Bristol-Myers Squibb Compnay

Viiv Healthcare UK (No. 4) Limited

Li Xu

Alicia Regueiro-Ren

Richard A Hartz

Nicholas A Meanwell

Sing-Yuen Sit

Yan Chen

Jie Chen

Jacob Swidorski

Zheng Liu

John E Macor

Richard Eric Olson

Yong-Jin Wu

Kenneth M Boy

Ny Sin

Jianliang Shi

Brian Lee Venables

Lorin A Thompson, Iii

Yunhui Zhang

Jason M Guernon

Dmitry S Zuev

Satheesh Kesavan Nair

Manoranjan Panda

Prasada Rao Jalagam

David S Yoon

Lorin A Iii Thompson

Iii Lorin A Thompson

The present disclosure relates to compounds of Formula (1), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods making and using such compounds and compositions.

Tetrahydropyran-based thiodisaccharide mimics as Galectin-3 inhibitors

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: with X selected from Ccycloalkyl, Ccycloalkenyl, Cspirocycloalkyl, Cspirocycloalkenyl, Coxacycloalkyl, Cdioxacycloalkyl, Coxacycloalkenyl, Cdioxacycloalkenyl, Ccyclodialkenyl, Coxacyclodialkenyl, Coxaspirocycloalkyl and Coxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is &#x2014;Calkyl-halo. These compounds are useful for the treatment of HIV and AIDS.

Triterpenoids with HIV maturation inhibitory activity

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, alkyl and alkenyl C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV: a compound of Formula I     The compounds are useful for the treatment of HIV and AIDS.

C-3 alkyl and alkenyl modified betulinic acid derivatives

The present disclosure provides a series of compounds of the formula (I) 

Compounds for the reduction of &#x3b2;-amyloid production

Compounds for the reduction of beta-amyloid production

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Middletown, CT, United States of America

Li Xu