Dartmouth College

King's College London

Wang, Li

Green, Kathy A.

Green, William R.

Noelle, Randolph J.

Spaller, Mark

Li Wang

Randolph J Noelle

Elizabeth Nowak

Mark R Spaller

Isabelle Lemercier

Sabrina Ceeraz

Janet Lines

William R Green

Kathy A Green

The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.

Vista antagonist and methods of use

The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates &#x3b1;CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon &#x3b1;CD3/&#x3b1;GITR stimulation. This protein has been designated T-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed. In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed.

Regulatory T cell mediator proteins and uses thereof

Methods for alleviating the suppression of humoral immunity by myeloid-dependent suppressor cells (MDSCs) are provided which include the administration of a VISTA antagonist and an iNOS/NO inhibitor in a subject in need thereof, e.g., subjects with cancer or infectious disease wherein VISTA is aberrantly expressed. This combination has been discovered to elicit a synergistic or additive effect on alleviating suppression of humoral immunity by VISTA which is elicited by MDSCs.

Use of vista agonists and antagonists to suppress or enhance humoral immunity

VISTA antagonist and methods of use

Growing community of inventors

Norwich, VT, United States of America

Li Wang