Lifecell Corporation

Li Ting Huang

Hui Xu

Yi Heng Chen

Hua Wan

Eric Stec

Sean Collins

Wenquan Sun

Nathaniel Bachrach

Rick T Owens

Kai-Roy Wang

Nimesh Kabaria

Patrick Leamy

Rick Owens

Yi Chen

The present application relates to use of transglutaminases to treat various products, including medical devices such as tissue grafts, tissue matrices or other tissue-derived materials, and synthetics. The transglutaminases can be applied to the medical devices to provide advantages such as adhesion resistance or abrasion resistance.

Transglutaminase treated products

Tissue compositions and methods of preparation thereof are provided. The tissue compositions can be used to treat or regenerate muscle tissue. The compositions can be configured to provide increased strength compared to other muscle matrices.

Devices including muscle matrix and methods of production and use

Methods of forming a composition for treatment, compositions for treatment, and methods of treatment with the compositions are provided. The methods can include coating a synthetic material substrate with a biologic material. A portion of the biologic material can be acid-swelled.

Mesh compositions and methods of production

Tissue products lacking a desired percentage of immunogenic epitopes, such as galactose alpha-1,3 galactose epitopes, are provided. Methods of making and using the tissue products are also provided.

Methods of removing alpha-galactose

Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix.

Method for enzymatic treatment of tissue products

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Branchburg, NJ, United States of America

Li Ting Huang