Theravance, Inc.

Theravance Biopharma R&d Ip, LLC

Electronic Arts Inc.

Li Li

Craig Husfeld

Mathai Mammen

YongQi Mu

Yu-Hua Ji

Yuhua Ji

Adam D Hughes

YuHua Ji

Sarah Dunham

Rick Andrew Lee

Eric L Stangeland

Trevor Mischki

Weijiang Zhang

Cameron Smith

Johnny Uy

Aaron Kushner

Richard D Wilson

Ioanna Stergiades

David A Oare

Shanzhong Zhu

Biao Zhou

Sijia Huang

Zhaosheng Zhang

Yan Chen

Robert S Chao

Davar Khossravi

This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar, R, R, R, R, R, R, and Rare as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Biphenyl compounds useful as muscarinic receptor antagonists

A player profile management system collects player data from various systems and generates and manages player profiles. A snapshot pipeline of the player profile management system generates a snapshot player profile associated with a player. The player profile management system receives, after generating the snapshot player profile associated with the player, player data associated with the player. An update pipeline of the player profile management system generates, based on the snapshot player profile and the player data associated with the player, an update player profile associated with the player.

Player profile management system

The invention provides compounds of the formula: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R, a, Z and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

Quaternary ammonium compounds useful as muscarinic receptor antagonists

The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R, R, a, X, Y, Y', Y&#x2033;, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

Guanidine-containing compounds useful as muscarinic receptor antagonists

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Sunnyvale, CA, United States of America

Li Li