Newbio Therapeutics, Inc.

Li Jian

Chun Yang

Nianhe Han

Deqiang An

Hang Yang

Peng Fei Zhu

Di Zeng

Baoxiang Wang

Mingzhen Li

Chengyu Hou

Disclosed are a type of tridentate linkers and use thereof. The tridentate linkers can be used to prepare an antibody drug conjugates as represented by formula I,L-(T-A-D)&#x2003;&#x2003;Iwherein, L is an antibody, antibody fragment or protein; T is a tridentate linker part; A is a cleavable linker group or a noncleavable linker part; D is a drug part; n is an integer of 0-8. The structure of the tridentate linker part is as represented by formula II, wherein, W is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or any combination thereof.

Tridentate connexon and use thereof

Derivatives of dolastatin 10 and uses thereof, the structures of which are shown as formula I, II, III and IV are provided. 

Derivatives of dolastatin 10 and uses thereof

A type of trimaleimide linkers and uses thereof are disclosed. The trimaleimide linkers can be applied for preparation of antibody-drug conjugate as shown by formula I: L-(T-A-D)I wherein, L is an antibody, antibody fragment or protein; T is a trimaleimide linker; A is a cleavable linker group or a noncleavable linker; D is a drug; n is an integer ranging from 1 to 8.

Trimaleimide linkers and uses thereof

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Shanghai, China

Li Jian