Chinese Academy of Sciences

Qilu Pharmaceutical Co., Ltd.

Kewpie Corporation

Fbc (Shanghai) Pharmaceutical Technology Co., Ltd.

Li Gan

Yang Liu

Hua Zhang

Yong Gan

Chunliu Zhu

Qingmin Yang

Xiaoqing Zheng

Xinxin Zhang

Yanan Wang

Jinlong Yang

A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and/or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.

Paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof

Growing community of inventors

Shanghai, China

Li Gan