Chung Hua University

Taiyen Biotech Co., Ltd.

Taipei Medical University

Li-Chern Pan

Po-Wei Lin

Jium Ming Lin

Chun-Wei Chen

Jium-Ming Lin

Wen-Fu Lai

Jung-Chou Oung

Pau-Yee Lim

Wen-Fu T Lai

Jun-Chou Oung

This invention relates to a bone implant that includes a bioinert substrate covered with a ceramic layer containing a plurality of indentations. The total surface area of the indentations is 30-70% of the total surface area of the ceramic layer. This invention also relates to a method of preparing such a bone implant. The method includes: (1) affixing a ceramic layer on the surface of a bioinert substrate; (2) forming a plurality of indentations in the ceramic layer, wherein the total surface area of the indentations is 30-70% of the total surface area of the ceramic layer; and (3) immobilizing a biopolymer onto the ceramic layer via covalent bonding.

Bone implants

The present invention provides a microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors. The present invention utilizes a micro-electro-mechanical process as well as a semiconductor process to integrate microarray bioprobes and an amplifier having bottom-gate thin film transistors on a flexible substrate. As such, a signal obtained by the microarray bioprobes can be amplified nearby to improve the signal-to-noise ratio and impedance matching. The microarray bioprobes are formed on the flexible substrate such that the present microarray bioprobe device can be disposed to conform to the profile of a living body's portion so as to improve electrical contact between the bioprobes and the living body's portion.

Microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors

The present invention provides a microarray bioprobe device integrated with a semiconductor amplifier module, which integrates micro array biological probes and thin film transistors on a flexible substrate by Micro-Electro-Mechanical System (MEMS) processes and semiconductor processes. A signal from the microarray bioprobe device is amplified through a near amplifier to increase signal-to-noise ratio and impendence matching. The micro array biological probes of the present invention are produced on the flexible substrate such that the micro array biological probes can be disposed to conform to the profile of a living body's portion and improving contact between the probes and living body's portion.

Microarray bioprobe device integrated with a semiconductor amplifier module on a flexible substrate

Growing community of inventors

Taipei, Taiwan

Li-Chern Pan