Qisda (Suzhou) Co., Ltd.

Jiangxi Caishi Pharmaceutical Technology Co., Ltd.

Ginkgo Pharama Co., Ltd.

Yikang Biotech (Suzhou) Co., Ltd.

Zhangjiagang Guotai-Huarong New Chemical Materials Co., Ltd

Li Chen

Xiaowen Li

Tao Jiang

Meng Zhang

Lei Chen

Ben Li

Qi Yun Shen

Feng Wang

Chao Wu

Jiadi Huang

Qing Shao

Wendie Wang

Jiaxin Lei

Songming He

Peizhe Li

Guangsha Zhang

Mingze Shi

Xiaoya Ding

Ruihong Jiang

Jianguo Yin

Tengsen Gao

Eric Chen

Derong Wang

Shibi Zhao

Xiaojian Xue

Shun Cai He

Hai Dong Wang

Chun Yang Chen

Peibing Zhai

Xiao Jun Xu

Sufang Gu

Yujiao Song

Yujuan Hua

Min Dai

Jiahao Xu

Xin Xie

Tao Fang

Juncai Chen

Xiangyun Yuan

Lei Shen

The present disclosure relates to the field of biomedicine, and in particular, to an improved mutant of a respiratory syncytial virus (RSV) fusion (F) protein and uses thereof. The mutant can form a trimeric structure without introducing a heterologous trimerization domain. Meanwhile, through mutation designs such as releasing internal electrostatic repulsion, deleting the furin cleavage site, truncating the C-terminal domain, and introducing interchain disulfide bonds, the protein is stabilized in the pre-fusion conformation and exhibits enhanced stability. The mutant in the present disclosure is highly immunogenic when used as a vaccine or a vaccine component and can induce the production of a high level of neutralizing antibodies in the immunized animal, which can be used in the preparation of a vaccine for the prevention or treatment of RSV infection, and can also be used as a reagent for the detection of RSV.

Mutants of respiratory syncytial virus fusion proteins

The present disclosure belongs to the field of medicinal chemistry, and relates to a novel pyridone derivative represented by Formula (I) or a stereoisomer, a pharmaceutically acceptable salt, a solvate or a crystal thereof, and use thereof in the preparation of a drug for preventing or treating diseases such as influenza type A viral infection and/or influenza type B viral infection, particularly use thereof as a PA subunit cap-dependent endonuclease inhibitor for preventing or treating diseases such as influenza type A viral infection and/or influenza type B viral infection. The compounds of the present disclosure have significant activity in inhibiting influenza endonuclease and influenza DNA, can be used either alone or in combination with a neuraminidase inhibitor, a nucleoside drug, a PB2 inhibitor, a PB1 inhibitor, an M2 inhibitor or other anti-influenza drugs, significantly shorten the time of influenza infection and reduces mortality, and have excellent clinical application prospects. 

Pyridone derivative, composition and use as antiviral drug thereof

An ejecting mechanism provides an ejecting executing portion driven by an ejecting driving portion for pushing a secondary machine out of a primary machine and for separating a secondary connector and a primary connector connected to each other. It allows the secondary machine to be ejected out of the primary machine automatically and prevents damage of the secondary connector and the primary connector caused by applying an external pulling force on the secondary machine directly. Furthermore, when a first external force overcomes a resilient driving force to push the secondary machine into a slot, the ejecting executing portion contacting with the secondary machine swings toward a rear end of a connecting surface of the primary connector. Additionally, an ejecting locking portion moving with the swing of the ejecting executing portion can be locked by a locking executing portion, such that the automatic ejection of the secondary machine is restrained.

Ejecting mechanism of a primary and secondary machine module, and primary and secondary machine module and primary machine therewith

A compound as represented by Formula (I) is provided, wherein groups are defined in the description. The compound is used as HCV protease inhibitor for treating HCV infection.

Macrocyclic compounds for suppressing replication of hepatitis C virus

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Suzhou, China

Li Chen