The Brigham and Women's Hospital, Inc.

Dana-farber-cancer Institute Inc.

National University of Singapore

Agency for Science, Technology and Research

Li Chai

Jun Qi

Anthony Varca

Daniel Geoffrey Tenen

Bee Hui Liu

Anders Poulsen

Cheng San Brian Chia

Kol Jia Yong

Todor Dimitrov

Provided herein are compounds that interrupt the function of SALL4. Also described are pharmaceutical compositions and medical uses of these compounds.

Small molecule inhibition of transcription factor SALL4 and uses thereof

Isolated peptides and pharmaceutical compositions comprising isolated peptides that bind to retinoblastoma binding protein 4 (RBBp4) and block the Spalt-Like Transcription Factor 4 (SALL4)-RBBp4 interaction are described. Methods of inhibiting binding of SALL4 to RBBp4 and methods of treating a subject having a disorder mediated by a dysregulation of SALL4 are also described.

Therapeutic spalt-like transcription factor 4 (SALL4) peptide

Described are methods of treating a solid tumor which expresses Spalt-Like Transcription Factor 4 (SALL4) and Phosphatase and Tensin Homolog (PTEN) in an individual in need thereof, comprising administering to the individual an effective amount of a composition that inhibits SALL4. In addition, the invention is directed to methods of detecting an aggressive cancer in an individual in need thereof as well as methods of detecting a poor prognosis of a patient with cancer in an individual in need thereof.

Spalt-like transcription factor 4 (SALL4) and uses thereof

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Boston, MA, United States of America

Li Chai