University of Kentucky Research Foundation

New Millennium Pharmaceutical Research, Inc.

Other

Safe Aid Products, Inc.

Lewis W Dittert

Anwar A Hussain

Bassam Tashtoush

Ashraf Traboulsi

Abeer M Al-Ghananeem

Thomas S Foster

Ali M Qaisi

This invention provides a method of rapidly and reliably delivering codeine, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route to produce rapid onset of beneficial effects in the treatment of pain or cough. The present invention further provides pharmaceutical compositions comprising codeine, and/or pharmaceutically acceptable salts thereof in a variety of unique pharmaceutical dosage forms, with and without other analgesic and/or antitussive compounds.

Intranasal codeine for the rapid suppression of cough and rapid relief of pain

The present invention is directed to a method for enhancing the delivery of delta-9-tetrahydrocannabinol (&ldquo;THC&rdquo;) to the brain of a mammal in need of treatment with this drug, by administering water-soluble prodrugs of THC intranasally.

Method for enhancement of delivery of THC by the administration of its prodrugs via the nasal route

This invention provides a method of rapidly and reliably delivering folic acid, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route to produce rapid onset of beneficial effects in the treatment or prevention of Alzheimer's Disease and stroke. The present invention further provides intranasal pharmaceutical compositions comprising folic acid, and/or pharmaceutically acceptable salts thereof in a variety of unique pharmaceutical dosage forms, with and without other anti-Alzheimer's or anti-stroke compounds.

Brain delivery of folic acid for the prevention of alzheimer's disease and stroke

This invention provides a method of rapidly and reliably delivering sildenafil, or derivatives thereof, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route so as to produce virtually instantaneous onset of beneficial effects in the treatment of erectile dysfunction. The present invention further provides pharmaceutical compositions comprising sildenafil, or derivatives thereof, and/or pharmaceutically acceptable salts thereof in a variety of unique pharmaceutical dosage forms, with and without apomorphine.

Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction

The present invention relates to N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters, and their use as agents for water disinfection and as mild oxidizing agents for the radiolabeling of oxidation-sensitive biomolecules.

Derivatives of N-chloro-N-methyl glucamine and N-chloro-N-methyl

N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters as

A kit and method of non-destructively radiolabelling a biomolecule substrate by halogenation, including the steps of: a) reacting a secondary amine with a chlorinating agent to produce an N-chloro secondary amine, (b) reacting the N-chloro secondary amine with a salt of a radiolabelled halogen to produce a radiolabelled halogenating agent, (c) reacting a solution of the biomolecule substrate with the radiolabelled halogenating agent, and (d) recovering a radiohalogenated biomolecule from the reaction of step (c). The kit and method allow for more complete iodination with a lessening of side reactions such as decomposition of the biomolecule substrate to be labelled.

Non-destructive method for radiolabelling biomolecules by halogenation

A fabric-safe bleaching and cleaning detergent composition comprising a bleach stable surfactant and a polymer coated halogenated glycoluril compound having the formula ##STR1## wherein each R is independently selected from hydrogen, C.sub.1 -C.sub.10 straight or branched chain alkyl, aryl or alkyl substituted aryl; each X is independently selected from hydrogen, fluorine, chlorine, bromine and iodine and at least one X is not hydrogen and n is 0 or 1. 1,3,4,6-tetrachloroglycoluril is the preferred bleaching agent. The polymer coating is capable of hydrating and dissolving at a pH of greater than 6.0, preferably 7.2 to 11.0, and more preferably 9.5 to 11.0. Polymeric pharmaceutical enteric coating materials are particularly suitable as a coating material for the present invention.

Novel polymer coated bleaching composition

The invention relates to a novel method of administering aspirin to achieve improved delivery thereof. The invention further relates to novel dosage forms of neutralized aspirin adapted for nasal administration, such as solutions, suspensions, gels and ointments. These dosage forms find utility in the treatment of conditions known to respond to the administration of aspirin, particularly in the treatment of migraine and in the mitigation of cardiovascular damage resulting from heart attack.

Growing community of inventors

Lexington, KY, United States of America

Lewis W Dittert