Cardiome Pharma Corp.

Correvio International Sàrl

Lewis Siu Leung Choi

Bertrand M C Plouvier

Gregory N Beatch

Doug Ta Hung Chou

Grace Jung

Tao Sheng

Anthony G M Barrett

Alfred Hedinger

Pirmin Ulmann

Marco Silvio Passafaro

Martin Kurz

Daniel Moeckli

Jeff Jiqun Zhu

Allen Davidoff

Yuzhong Liu

Aregahegn Yifru

Alan M Ezrin

Elizabeth L S Cheu

Adewale Eniade

Betrand Mc Plouvier

Richard Wall

Bertrand Plouvier

Marco S Passafaro

Anthony GM Barrett

Anthony GM Barett

Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.

Synthetic process for aminocyclohexyl ether compounds

Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed. 

Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.

Aminocyclohexyl ether compounds and uses thereof

Prodrugs of ion channeling modulating compounds, including, for example, prodrugs of the ion channel modulating compound of the following formula: are described herein, as well as methods of making and using such prodrugs and pharmaceutical compositions containing such prodrugs. 

Prodrugs of ion channel modulating compounds and uses thereof

This invention is directed to drug conjugates of certain ion channel modulating compounds having the following formula: wherein A, X, R, R, R, R, R, LB, L and DM are defined herein, including isolated enantiomeric and diastereomeric isomers thereof, and mixtures thereof. Pharmaceutical compositions and methods of use are also disclosed.

Drug conjugates of ion channel modulating compounds

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Burnaby, Canada

Lewis Siu Leung Choi