University of British Columbia

Cardiome Pharma Corp.

Ucb Farchim Sa

Lewis S L Choi

Bertrand M C Plouvier

Gregory N Beatch

Yuzhong Liu

Clive Pete Page

Pieter Rutter Cullis

Myrna Monck

Austin Bailey

Doug Ta Hung Chou

Jun Nakano

James P Kutney

Grace Jung

Camille A Boulet

Hiroki Tsukamoto

Michael McHugh

Merged compounds of ion channel modulating compounds, including, for example, merged compounds of the ion channel modulating compound of the following formula: (I) are described herein, as well as methods of making and using such merged compounds and pharmaceutical compositions containing such merged compounds. 

Merged ion channel modulating compounds and uses thereof

The present invention relates to liposomes and virosomes and, more particularly, to liposomal and virosomal delivery systems for transporting materials such as drugs, nucleic acids and proteins.

Fusogenic liposomes

Novel compounds and pharmaceutical compositions containing such compounds and possessing anti-tussive activity, and a method of administering the same to warm-blooded animals, including humans.

Quarternary ammonium compounds

Compounds and pharmaceutical compositions containing such compounds and possessing anti-tussive activity, and a method of administering the same to warm-blooded animals, including humans.

Indole-containing quaternary ammonium compounds

The present invention relates to the synthesis of dimer alkaloid compounds, particularly those of the Catharantus (Vinca) family, from an indole unit, such as cantharanthine, and a dihydroindole unit, such as vindoline. A multi-step process is disclosed including the steps of (1) of 1,4-reduction of a first dimeric iminium intermediate to an enamine compound by reaction with a 1,4-dihydropyridine compound; (2) oxidative transformation of the resulting enamine to a second iminium intermediate under controlled aeration; (3) reduction of the second iminium intermediate to form the target dimer alkaloid compounds. The entire process can be conducted in a one-pot operation to obtain the target compounds without isolation of the intermediates.

Process of synthesis of 3&prime;,4&prime;-anhydrovinblastine, vinblastine and vincristine

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Burnaby, Canada

Lewis S L Choi