Schering Corporation

Becton Dickinson and Company Limited

University of California

Other

Leland Stanford Junior University

Lewis L Lanier

Joseph H Phillips

Alexander B H Bakker

Daniel M Gorman

Terrill K McClanahan

Gosse Jan Adema

Linde Meyaard

Gerard Zurawski

Sandra M Zurawski

Chiwen Chang

Jeffrey A Bluestone

Jody Lynn Baron

Noel L Warner

Peter R Parham

Sang-Mo Kang

Anne L Jackson

Koetsu Ogasawara

Courtney Crane

Arnon Nagler

Andrew T Parsa

Jose Aramburu Beltran

Miguel Lopez-Botet

Jennifer E Gumperz

Virginia M Litwin

The present disclosure is directed toward measurement of expression of one or both of an activating Natural Killer (NK) cell receptor and its ligand(s) on peripheral blood cells as a means to assess solid tumor burden. In particular, the present disclosure provides tools for assessing cancer recurrence or risk thereof following reduction of a solid tumor, and for developing a treatment regime for a cancer patient.

Assessment of solid tumor burden

The present invention relates to methods and compositions for treating and/or preventing autoimmune and/or inflammatory disease. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D.

Modulation of NKG2D for prolonging survival of a hematopoietic graft

The present invention relates to methods and compositions for treating and/or preventing inflammation associated with viral infection and solid organ transplant rejection. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D.

Modulation of NKG2D

Nucleic acids encoding various monocyte cell proteins from a primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using reagents and related diagnostic kits are also provided.

Antibodies that bind DNAX leukocyte associated immunoglobulin-like receptor

Modulation of NKG2D for treating or preventing solid organ allograft rejection

The purification and isolation of various genes which encode mammalian cell surface polypeptides. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells, e.g., lymphoid and myeloid, are provided, along with methods for their use.

DAP12 nucleic acids

MDL-1 polypeptides

Binding compounds to DAP12 proteins

Antibodies and fragments thereof to MDL-1 protein

Nucleic acids encoding various monocyte cell proteins from a primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using reagents relating to nucleic acids encoding monocyte cell proteins, and diagnostic kits, are also provided.

Antibodies that specifically bind DNAX leukocyte associated immunoglobulin-like receptor

Nucleic acids encoding mammalian cell membrane protein MDL-1

DNA clones encoding a receptor in the Ig superfamily and a related soluble variant have been isolated from a human monocyte library. The invention provides receptor polypeptides, nucleic acids encoding them, expression vectors, and transformed cells for recombinant production of the polypeptides.

Ig superfamily `dlair` receptors expressed in monocytes

NK cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen. Methods of using those reagents and diagnostic kits are also provided.

Purified mammalian NK antigens and related reagents

The invention provides nucleic acids and polypeptides encoding an NK cell surface antigen from a mammal, as well as antibodies that specifically bind the NK cell surface antigen. Methods of using the nucleic acids, polypeptides, and antibodies are provided, including diagnostic kits comprising one or more of these reagents.

Nucleic acids encoding kp43 protein and antigenic fragments thereof

Antibodies which specifically bind to an NK cell surface antigen from a mammal, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of using said reagents and diagnostic kits are also provided.

Antibodies to mammalian NK antigens and uses

Growing community of inventors

Los Altos, CA, United States of America

Lewis L Lanier