Medical University of South Carolina

Lewis Howard Bowman

Matthew W Endres

Vicki Bowman Vance

Vicki Sue Vance

Allison Mallory

Viki Bowman Vance

Vicki Vance Bowman

Compositions and methods for modulating nucleotide sequence expression, particularly for modulating gene expression in plants, are provided. The compositions comprise precursor RNA constructs for the expression of an RNA precursor. The precursor RNA construct comprises a promoter that is expressed in a plant cell driving the expression of a precursor RNA having a microRNA. The miRNA is complementary or partially complementary to a portion of a target gene or nucleotide sequence and function to modulate expression of the target sequence or gene. In this manner, the RNA precursor construct can be designed to modulate expression of any nucleotide sequence of interest, either an endogenous plant gene or alternatively a transgene. Transformed plants, tissues, cells and seeds are also provided.

Compositions and methods for the modulation of gene expression in plants

Compositions and methods are described which use RAV proteins and genes that encode such proteins to regulate RNA silencing in plant cells. Novel ntRAV proteins and genes are also described.

Endogenous regulator of RNA silencing in plants

Growing community of inventors

Columbia, SC, United States of America

Lewis Howard Bowman