Purigen Biosystems, Inc.

Leland Stanford Junior University

Lewis A Marshall

Juan G Santiago

Klint Aaron Rose

Nathan P Hoverter

Amy L Hiddessen

Anita Rogacs

Janine Mok

Yatian Qu

Andrew Lee

Matthew S Munson

Sean Arin

Michael Christopher De Renzi

Michael Christopher DeRenzi

Various aspects of the present disclosure are directed toward methods and apparatuses for interacting a first liquid and a second liquid in one or more fluidic channels of a capillary structure. The methods and apparatuses can include providing at least one capillary barrier that positions a meniscus of the first liquid at a fluid-interface region using capillary forces within the capillary structure. Additionally, a path is provided along one of the channels for the second liquid to flow toward the fluid-interface region. Additionally, gas pressure is released, via a gas-outflow port, from the fluid-interface region while flow of the first liquid is arrested. Further, the first liquid and the second liquid contact in the fluid-interface region with the capillary barrier holding the first liquid at the fluid-interface region.

Capillary barriers for staged loading of microfluidic devices

The present disclosure relates to fluidic systems and devices for processing, extracting, or purifying one or more analytes. These systems and devices can be used for processing samples and extracting nucleic acids, for example by isotachophoresis. In particular, the systems and related methods can allow for extraction of nucleic acids, including non-crosslinked nucleic acids, from samples such as tissue or cells. The systems and devices can also be used for multiplex parallel sample processing.

Isotachophoresis for purification of nucleic acids

Systems, devices, and methods for isotachophoresis

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Oakland, CA, United States of America

Lewis A Marshall