Provivi, Inc.

Les Laboratoires Servier

Vernalis &r&d) Ltd.

Ximo Ag

Verbio Vereinigte Bioenergie Ag

Givaudan S.a.

Elevance Renewable Sciences, Inc.

Vernalis Limited

Levente Ondi

Georg Emil Frater

Florian Toth

Keith Michael Wampler

Pedro Coelho

Vu Bui

Jeno Varga

Hasan Mehdi

Krisztian Lorincz

Peter Meinhold

Olivier Geneste

James Brooke Murray

I-Jen Chen

James Edward Paul Davidson

András Kotschy

Zoltán Szlávik

Szabolcs Sipos

Balázs Bálint

Zoltán Szabó

Ágnes Proszenyák

Márton Csékei

Csaba Hegedus

Emmanuel Robe

Agota Bucsai

Maïa Chanrion

Steven Alan Cohen

Andreas Goeke

Martin Alan Lovchik

Françoise Perron-Sierra

Attila Paczal

David Rozzell

Alain Bruno

Gábor Radics

Paul Nicholas Davey

Gabor Eros

Arthur Floruti

Henrik Gulyás

Georg FRÁTER

The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula: wherein:

Compounds and the use thereof in metathesis reactions

The invention relates to a method of forming an olefin from a first olefin and a second olefin in a metathesis reaction, comprising step (i): 

Metathesis catalysts and reactions using the catalysts

Methods for preparation of olefins, including 8- and 11-unsaturated monoenes and polyenes, via transition metathesis-based synthetic routes are described. Metathesis reactions in the methods are catalyzed by transition metal catalysts including tungsten-, molybdenum-, and ruthenium-based catalysts. The olefins include insect pheromones useful in a number of agricultural applications.

Synthesis of pheromones and related materials via olefin metathesis

In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: andb) converting the metathesis product to the fatty olefin derivative. Each Ris independently selected from H, Calkyl, and Calkenyl; Ris Calkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.

Production of fatty olefin derivatives via olefin metathesis

Compounds of formula (I): wherein R, R, R, R, R, R, R, R, R, W, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.

Bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them

In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and

Compounds of formula (I): wherein R, R, R, R, R, R, X, Y, A, E and n are as defined in the description. Medicinal products containing the same which are useful in treating a condition requiring a pro-apoptotic agent.

Aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them

A method is provided of forming an olefin from a first olefin and a second olefin in a metathesis reaction, comprising reacting the first olefin with the second olefin in the presence of a compound that catalyzes the metathesis reaction such that the molar ratio of the compound to the first or the second olefin is from 1:500 or less, and the conversion of the first or the second olefin to the olefin is at least 30%.

A method of forming a macrocyclic musk compound comprising the steps of:&#x2014;

Process involving cross metathesis of olefins

The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula (I) wherein: M is a Group 6 metal atom; X is an oxygen atom, &#x2550;N&#x2014;R, &#x2550;N&#x2014;N(R)(R) or &#x2550;N&#x2014;O&#x2014;R, Rand Rindependently being various substituents, such as aryl or heteroaryl, each optionally substituted; n is 0 or 1; Ris a neutral ligand; Ris hydrogen or an organic substituent; Ris an aryl or heteroaryl group, each optionally substituted; Ris an anionic ligand; and Ris an anionic ligand, such as a pyrrolide, a pyrazolide, an imidazolide, an indolide, an azaindolide, or an indazolide, each optionally substituted. 

The invention relates to a method of forming an olefin from a first olefin and a second olefin in a metathesis reaction, comprising step (i): (i) reacting the first olefin with the second olefin in the presence of a compound that catalyzes said metathesis reaction such that the molar ratio of said compound to the first or the second olefin is from 1:500 or less, and the conversion of the first or the second olefin to said olefin is at least 50%, characterized in that as compound that catalyzes said metathesis reaction a compound of formula (A) is used: wherein M is Mo or W; Ris aryl, heteroaryl, alkyl, or heteroalkyl; optionally substituted; Rand Rcan be the same or different and are hydrogen, alkyl, alkenyl, heteroalkyl, heteroalkenyl, aryl, or heteroaryl; optionally substituted; Ris alkyl, alkoxy, heteroalkyl, aryl, heteroaryl, silylalkyl, silyloxy, optionally substituted; and Ris a residue R&#x2014;X&#x2014;, wherein X&#x2550;O and Ris aryl, optionally substituted; or X&#x2550;S and Ris aryl, optionally substituted; or X&#x2550;O and Ris (R, R, R)Si; wherein R, R, Rare alkyl or phenyl, optionally substituted; or X&#x2550;O and Ris (R, R, R)C, wherein R, R, Rare independently selected from phenyl, alkyl; optionally substituted; and to the catalysts used in the method. 

A method for treating a substrate prior to a metathesis reaction includes treating the substrate with a first agent configured to mitigate potentially adverse effects of one or more contaminants in the substrate on a catalyst used to catalyze the metathesis reaction. The treating reduces a level of the one or more contaminants by an amount sufficient to enable the metathesis reaction to proceed at a substrate-to-catalyst molar ratio of at least about 7,500 to 1. Methods for metathesizing substrates are described.

Methods for treating substrates prior to metathesis reactions, and methods for metathesizing substrates

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Veresegyhaz, Hungary

Levente Ondi