Ljl Biosystems, Inc.

Beckman Instruments, Inc.

Chiron Corporation

Lev J Leytes

Douglas N Modlin

Amer El-Hage

Glenn R Edwards

John C Owicki

Jon F Petersen

William G Burton

Michael S Urdea

David P Stumbo

Brian David Warner

Samuel Ascher Marquiss

Rick T Smethers

Samuel Burd

Christopher G Cesar

Todd E French

Harry A Penhasi

Joseph S Leytes

Robert R Shadel

Yong Paik

Derrick A Richardson

Enal S Razvi

James S Richey

Daniel H Scharff

The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.

Integrated sample-processing system

Sample-holding devices and systems for efficiently utilizing relatively small-volume fluid samples.

Sample-holding devices and systems

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance energy transfer (FRET) detection, and (3) allele-specific nucleotide incorporation, using primer extension with luminescence polarization (FP) detection. More specifically, the methods may include (1) locating a sample containing a nucleic acid material at an examination site, (2) illuminating the sample, (3) detecting light transmitted from the sample, and (4) determining the presence, absence, and/or identity of a nucleic acid target in the sample using the light transmitted from the sample.

Methods and apparatus for detecting nucleic acid polymorphisms

A moveable control unit for a high-throughput analyzer that can be operatively mounted at a plurality of locations on the analyzer housing.

Moveable control unit for high-throughput analyzer

A self-contained assembly for assaying an analyte in a liquid sample. The pair of disc-like rotatable plates forming the assembly are relatively rotatable to align reagent reservoirs in one plate with a reaction well in the other plate, for sequential addition of multiple reagents, either in liquid or solid form, to the reaction well. In one embodiment, the reaction well includes solid-phase particles which can be transferred from the reaction well to spaced wells in the assembly by a combination of relative movement of the plate, and rotation of the entire assembly.

Self-contained assay assembly and apparatus

A mixing valve includes a housing having inlet ports and an outlet port that intersect at a valve chamber. A valve core within the valve chamber includes passages in fluid communication with the inlet and outlet ports. The passages intersect at a cavity within the valve core. An elastomeric seal retained within the cavity sealingly engages the valve core around the passages in the absence of fluid pressure in the inlets. Injection of a pressurized fluid in one of the inlets causes the seal to move away from both the corresponding inlet passage to permit fluid flow from the pressurized inlet port to the outlet port and compresses the seal around the other inlet port to provide a tighter seal than existed before application of pressure to the first port.

Mixing tee check valve and method

A column for use in DNA synthesis. The column is transparent and is disposable to allow access to the resin beads within the column. The column includes end caps which are engageable with a housing and a screw to secure the column in the housing.

Removable synthesis column

Growing community of inventors

Palo Alto, CA, United States of America

Lev J Leytes