A.v. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences

Institut Neftekhimicheskogo Sinteza Imeni A.v.topchieva Rossiiskoi

Orex Pharmaceutical Development Corp.

Lev I Valuev

Nikolai Alfredovich Plate

Vladimir Alexnadrovich Knyazhev

Tatyana Alexandrovna Valueva

Jay M Henis

Alexandr Sergeevich Ametov

Ljudmila Konstantinovna Staroseltseva

Alexander S Ametov

Ludmila K Staroseltseva

Vladimir A Sinani

Lubov D Uzhinova

A therapeutic-containing composition adapted for the oral administration of a biologically active material which comprises a water insoluble but water swellable polymer chemically modified with an enzyme inhibitor containing a chemical functionality which has an interactive affinity for target receptors located on the transport barrier walls of the digestive tract of the intended recipient, and at least one therapeutic of low oral bioavailability.

Protein-containing polymer composition for oral administration

A hemocompatible composition comprising a polymer containing at least one pharmacologic material chemically bonded to a polymer backbone. Such compositions may be obtained by reacting a pharmacologic material with a compound containing a polymerizable group (e.g., an acyl halide) and thereafter either copolymerizing the acylated material with one or more copolymerizable monomers or first irradiating a backbone polymer and thereafter grafting the acylated pharmacologic material onto the irradiated polymer. The resulting products are hemocompatible and may be used in the manufacture of medical devices which come in contact with blood or other bodily fluids. The advantage of chemically bonded pharmacologic materials is that they are not leached out and retain their pharmaceutical effectiveness for a long period of time. The compositions may contain one or more additional pharmacologic materials which are physically admixed with polymers containing bonded pharmacologic materials.

Process for preparing biologically compatible polymers and their use in

An insulin-containing polymer composition intended for the oral administration of insulin, which comprises a hydrophilic polymer modified with an inhibitor of proteolytic enzyme, insulin and water, wherein the inhibitor of proteolytic enzymes is ovomucoid isolated from duck or turkey egg whites.

Insulin-containing polymer composition for oral administration

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Moscow, Russia

Lev I Valuev