Medlogic Global Corporation

Baroid Drilling Fluids, Inc.

Yeda Research and Develpment & Co. Ltd

The Weizmann Institute of Science

Gel Sciences, Inc.

Madash LLC

Lev Bromberg

E C Lupton

Barry Joseph Hand

Xiaohong Yu

David Diggs

Barry Hand

Mara Stein

Michael Orkisz

M J Timm

Marie Kearney

Eyal S Ron

Marina Temchenko

Gideon Levin

Matthew E Schiller

Elmer C Lupton, Jr

George McKinney

Mary Jo Timm

Elmer Cornelius Lupton

A pharmaceutic composition includes a pharmaceutically acceptable carrier, comprising a reverse thermally viscosifying polymer. The polymer includes a linear block copolymer, wherein at least one block comprises a poloxamer; and at least one block comprises a biocompatible polymer or oligomer, in an aqueous medium. The composition also includes an active agent which imparts a pharmaceutic or cosmetic effect. The composition viscosities in response to an environmental stimulus. The composition is suitable for administration of the pharmaceutical agent across dermal, otic, rectal, vaginal, ophthalmic, esophageal and nasal mucosal membranes.

End modified thermal responsive hydrogels

The materials include non-polyampholite crosslinked polymers and gels based on a polymer which in uncrosslinked form is substantially soluble in ionic fluids and substantially insoluble in water. The materials change their state of hydration in response to an environmental trigger. The disclosed materials are useful as drilling, completion or workover fluids in wells such as hydrocarbon producing wells. According to the disclosed method, crosslinked polymers or gels are introduced into a stratum, blocking or bridging the pores of the stratum. Thereafter, an environmental condition is changed to cause the hydrated material to become less hydrated to unblock the pores allowing production from the well.

Drilling compositions and methods

Methods and compositions for encapsulated polymeric gels swollen with nonaqueous reactive materials are provided. The methods include gel synthesis, swelling of a gel precursor with a first nonaqueous reactive material, and encapsulation of the swollen gel with a second nonaqueous reactive material. Gels precursors may be synthesized from crosslinking polymers, or alternatively, may be formed by crosslinking and polymerizing a monomer starting material. An accelerator may be utilized to facilitate swelling of the gel precursor with the first nonaqueous reactive material. Foams and composites may also be swollen with the first nonaqueous reactive material. The swollen gel is then contacted with a second nonaqueous reactive material such that an encapsulation layer is formed thereby. The encapsulated gels may be stored for subsequent use. The methods further include release of the first nonaqueous reactive material encapsulated within the gel under conditions which compromise the integrity of the encapsulation layer. The released first nonaqueous reactive material is then reacted with a nonaqueous reactive material, the reaction product being a useful product for a variety of applications such as coatings, adhesives, sealings, caulking, laminating materials, electrical coatings and the like.

Encapsulated materials

A responsive polymer network exhibiting the property of reversible gelation in response to a change in an environmental stimulus is provided. The aqueous solution of the network polymer, comprises about 0.01 to 20 wt % by weight of a responsive component and about 0.01 to 20 wt % by weight of a structural component capable of supporting and interacting with the responsive component. The aqueous composition exhibits at least a five-fold increase in viscosity upon gelation. The gelation may be triggered by a change in an environmental stimulus, such as temperature, pH and ionic strength.

Responsive polymer networks and methods of their use

Gelled material compositions with modified halopolymer

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Lynn, MA, United States of America

Lev Bromberg