Amgen Inc.

Leticia M Toledo-Sherman

Jean E Bemis

David M Armistead

Joseph J Nunes

Gregory J Habgood

Joseph L Kim

Vinod Francis Patel

Daniel Elbaum

Lucian V DiPietro

Perry M Novak

Stephanie Geuns-Meyer

Xiaotian Zhu

John Laird Buchanan

Teresa L Marshall

The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptoms.

Kinase inhibitors

The invention relates to inhibitors of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms.

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Venice, CA, United States of America

Leticia M Toledo-Sherman