Institute of Bioorganic Chemistry

Bioinfobank Sp. Z O. O.

Uniwersytet Medyczny Im. Karola Marcinkowskiego

University of Warsaw

Instytut Biologii Medycznej Polskiej Akademii Nauk

Instytut Bioinfobank Sp. Z O.o.

Leszek Rychlewski

Jan Barciszewski

Eliza Wyszko

Katarzyna Rolle

Lech Celewicz

Jaroslaw Dastych

Anna Bujko

Magdalena Lukasiak

Miroslawa Skupinska

Ewelina Rodakowska

Miroslawa Barciszewska

Iwona Gawronska

Ryszard Zukiel

Stanisaw Nowak

Krzysztof Ciszewski

The subject of the present invention is a method of modifying proteinaceous toxins through the addition of an NLS motif. The resulting cytotoxin facilitates the selective elimination of proliferating cells, particularly tumor cells.

Recombinant cytotoxin as well as a method of producing it

The subject matters of this invention are a sequence of double-stranded RNA: ATN-RNA, intervention using interference RNA (iRNAi), use of a sequence of double-stranded RNA: ATN-RNA, a method of treating a brain tumor and a method of inhibiting a brain tumor cells which express tenascin, a kit for inhibiting cancer cell which expresses tenascin and a method for a kit preparation in a brain tumor therapy. Malignant gliomas preferentially express a number of surface markers that may be exploited as therapeutic targets, including tenascin-C, an extracellular matrix glycoprotein that is ubiquitously expressed by malignant gliomas and probably contributes to tumor cell adhesion, invasion, migration and proliferation. For tenascin-C inhibition, RNA interference intervention (iRNAi) approach have been applied.

Sequence of dsRNA: ATN-RNA specific for tenascin-C

The subjects of the present invention are a method of manufacturing 3-(4-hydroxyphenyl)propanoic acid amide, its application in the manufacture of anti-aging compositions and an anti-aging composition. As phloretamide possesses a series of biological properties it might be use as a composition for skin having excellent anti-aging effect to prevent the sagging of skin and loss of luster.

Method of manufacturing 3-(4-hydroxyphenyl)propanoic acid amide, its application in the manufacture of anti-aging compositions and anti-aging composition

Growing community of inventors

Poznan, Poland

Leszek Rychlewski