Northwestern University

University of Illinois

Intellect Neurosciences Inc.

Lester I Binder

Nicholas Kanaan

Scott Thomas Brady

Gerardo Andres Morfini

Nichole E LaPointe

Daniel G Chain

Yifan Fu

Kristina Patterson

The present invention is a composition and method for the prevention and treatment of a tauopathy. The composition of the invention includes N-terminal amino acid residues of the tau protein, which have been identified as being involved in toxic activation of a PP1/GSK3 signaling cascade and inhibition of fast axonal transport in human tauopathies.

Composition and method for preventing or treating a tauopathy

Composition and method for treating a tauopathy

Antibodies selective for pathological tau dimers and/or prefibrillar pathological tau oligomers, immunogenic peptides and epitopes of these antibodies, hydridomas producing these antibodies, uses of these antibodies, immunogenic peptides and epitopes in preparation of pharmaceutical compositions for the treatment of tauopathies, and uses of these antibodies, immunogenic peptides, epitopes and pharmaceutical compositions in the treatment of tauopathies are described. Also described are uses of these antibodies, immunogenic peptides, epitopes in diagnosis and monitoring of tauopathies.

Antibodies selective for pathological tau dimers and prefibrillar pathological tau oligomers and their uses in treatment, diagnosis and monitoring of tauopathies

Growing community of inventors

Chicago, IL, United States of America

Lester I Binder