Leland Stanford Junior University

Watkins- Johnson Company

Lester A Roberts

Robert L White

Maneesh Jain

Aris Silzars

David J Bates

The invention includes devices and methods for forming random arrays of magnetic particles, arrays formed using these devices and methods, and to methods of using the arrays. The invention provides an assembly (chip) with magnetic domains that produce localized magnetic fields capable of immobilizing magnetic particles such as commercially available magnetic beads. Probe or sensor molecules can be coupled to the beads, which are then dispersed on the assembly, forming a random order array. The arrays can be used for analyzing samples, targets, and/or the interaction between samples and targets. The invention finds particular use in processes such as high-throughput genotyping and other nucleic acid hybridization-based assays.

Devices and methods to form a randomly ordered array of magnetic beads and uses thereof

A laminar flow electron gun employing a narrow, elongated cathode for forming a rectangular beam and a plurality of electrodes having narrow, elongated apertures cooperating with said cathode to draw electrons from said cathode and operate on the electrons to focus the rectangular beam onto a target by providing a parallel flow region adjacent said cathode, followed by a divergent flow region, in turn, followed by a convergent flow or focusing region.

Growing community of inventors

Palo Alto, CA, United States of America

Lester A Roberts