The Upjohn Co.

Lester A Dolak

Thomas M Castle

Alice L Laborde

Oldrich K Sebek

Fritz Reusser

Betty R Hannon

Charles K Marschke

Thomas F Brodasky

Durey H Peterson

Alexander D Argoudelis

John H Coats

LeRoy E Johnson

Clarence DeBoer

Walter T Sokolski

Clarence De Boer

Alma Dietz

Novel antibiotic U-68,204 is produced in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces thiolactonus, NRRL 15439. This antibiotic is active against various Gram-positive bacteria. Thus, antibiotic U-68,204 can be used in various environments to eradicate or control such bacteria.

Antibiotic producing Streptomyces thiolactonus

Composition of matter and process

Antibiotic U-66,026 is produced in a fermentation under controlled conditions using the microorganism Alcaligenes sp., NRRL B-15269. Enhanced fermentation of titers U-66,026 are obtained when Alcaligenes sp., NRRL B-15269, is cultivated in mixture with Streptomyces plicatus strain 395, NRRL 15273. Antibiotic U-66,026 is a useful antibiotic which has antifungal activity.

Novel antibiotic U-64,864 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces braegensis Dietz sp.n., NRRL 12567. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Thus, antibiotic U-64,864 can be used in various environments to eradicate or control such bacteria.

Antibiotic producing streptomyces

Novel antibiotic U-64,767 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces macronensis Dietz sp.n., NRRL 12566. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus and Streptococcus pyogenes. It is also active against the Gram-negative bacterium Streptococcus pneumoniae. Thus, antibiotic U-64,767 can be used in various environments to eradicate or control such bacteria.

Process for production of antibiotic U-64,767 using Streptomyces

Novel antibiotic 3-trehalosamine (U-59,834) producible in a fermentation under controlled conditions using the new microorganism Nocardiopsis trehalosei sp. nov., NRRL 12026. This antibiotic is active against Gram-positive bacteria, for example, Staphylococcus aureus, Bacillus subtilis, and Diplococcus pneumoniae. Thus, 3-trehalosamine can be used in various environments to eradicate or control such bacteria. Antibiotic 3-trehalosamine can be shown by the following structural formula: ##STR1##

Process of producing 3-trehalosamine by fermentation

Biologically pure culture of Nocardiopsis trehalosei sp. nov.

Novel antibiotic U-60, 394 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces woolenses, Dietz and Li sp.n., NRRL 12113. This antibiotic is strongly active against various Gram-positive bacteria, for example, Staphylococcus aureus and Streptococcus hemolyticus. It is also strongly active against the Gram-negative bacterium Streptococcus pneumoniae. Thus, antibiotic U-60, 394 can be used in various environments to eradicate or control such bacteria.

The present invention relates to a fermentation process for producing allylic methyl-hydroxylated novobiocin and derivatives thereof.

Allylic methyl-hydroxylated novobiocins

3-Trehalosamine compounds

The present invention relates to processes for the chemical oxidation of novobiocin-type compounds (I) to their corresponding hydroxy derivative (II) or aldehyde (III) and formation of novobiocin derivatives from these oxidation products. The oxidation products and derivatives have antibacterial activity.

Chemical oxidation of novobiocin and products obtained therefrom

The present invention relates to a fermentation process for producing allylic methyl-hydroxylated novobiocin and derivatives thereof. These hydroxy novobiocins (II) are useful as antibiotics.

Derivatives of novobiocin

Novel antibiotic 354 (U-54,703) producible in a fermentation under controlled conditions using the new microorganism Streptomyces puniceus subsp. doliceus, NRRL 11160. This antibiotic is active against Gram-negative bacteria, for example, Pseudomonas and Proteus species. Thus, antibiotic 354 can be used in various environments to eradicate or control such bacteria.

Growing community of inventors

Plainwell, MI, United States of America

Lester A Dolak