American Home Products Corporation

Ayerst, Mckenna & Harrison, Inc.

Leslie G Humber

Christopher A Demerson

Andre A Asselin

Thomas A Dobson

Ivo L Jirkovsky

Dominick Mobilio

Gervais Dionne

Clara Revesz

Alan Howard Katz

Jean-Marie Ferland

George Santroch

Francois T Bruderlein

Philip Floyd Hughes

Amedeo Failli

Adolf H Philipp

Danilo A Crosilla

Dominick Anthony Quagliato

Gerald L Reuter

Jean A Gauthier

Joseph P Sabatucci

Eckhardt S Ferdinandi

Kazimir Sestanj

Francesco Bellini

Karel Pelz

Wilbur Lippman

This invention discloses organoleptically acceptable formulations containing non-solubilized S(+) 1,8-diethyl-1,3,4,9-tetrahydropyrano�3,4-b!indole-1-acetic acid, preferably with an acidic component, also known as S(+)etodolic acid or S(+)etodolac.

Oral Formulations of S(+)-etodolac

This invention discloses organoleptically acceptable formulations containing S(+)-2-(p-isobutylphenyl)-propionic acid, also known as S(+) ibuprofen.

Oral formulations of S(+)-ibuprofen

Disclosed herein are novel benzopyrans having pharmacological activity, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of hypertension.

Process for preparing benzopyran derivatives

Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.

Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids

Novel antihypertensive benzopyran derivatives

Process for the production of substituted 2-oxocyclohexaneacetic acid esters and intermediates used for their production. The substituted 2-oxocyclohexaneacetic acid esters are themselves useful intermediates for the manufacture of substituted 2,3,4,9-tetrahydro-1H-carabazole-1-acetic acid derivatives having useful analgesic and anti-inflammatory activity.

Process for the production of substituted 2-oxocyclohexaneacetic acid

Process for the production of substituted 2-oxocyclohexaneacetic acid esters and intermediates used for their production. The substituted 2-oxocyclohexaneacetic acid esters are themselves useful intermediates for the manufacture of substituted 2,34,9-tetrahydro-1H-carbazole-1-acetic acid derivatives having useful analgesic and anti-inflammatory activity.

Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic and anti-inflammatory agents.

Production of substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid

Production of indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.

Production of substituted 1,3,4,9-tetrahydropyrano(3,4-B)indole-1-acetic

Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods of their preparation and use are disclosed. The compounds are useful analgesic and anti-inflammatory agents.

Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives,

Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at position 8. The derivatives are useful anti-inflammatory and analgesic agents and methods and chemical intermediates for their preparation are also disclosed.

Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids

Process for the production of substituted 2-oxocyclohexaneacetic acid esters and intermediates used for their production. The substituted 2-oxocyclohexaneacetic acid esters are themselves useful intermediates for the manufacture of substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives having useful analgesic and anti-inflammatory activity.

Substituted 2-oxocyclohexaneacetic acid esters

Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation. The compounds are useful analgesic and anti-inflammatory agents.

Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic and antiinflammatory agents.

Growing community of inventors

Dollard des Ormeaux, Canada

Leslie G Humber