The University of Texas System

Other

Wyeth Holdings Corporation

Leslie D Cope

Eric J Hansen

Isobel Maciver

Christoph Aebi

Michael J Fiske

Ross A Fredenburg

Mark S Hanson

Gregory P Jarosik

The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study ofare disclosed.

UspA2 nucleic acid of moraxella catarrhalis

[object Object]

The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (ie. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study ofare disclosed.

The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of are disclosed.

UspA1 and UspA2 antigens of Moraxella catarrhalis

The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of,are disclosed.

USPA1 and USPA2 antigens of Moraxella catarrhalis

Disclosed are hxuB and hxuC genes and DNA segments from H. influenzae such as H. influenzae type b (Hib) and nontypeable H. influenzae (NTHI). The HxuB and HxuC proteins, being surface expressed, are contemplated for use in the preparation of vaccines against pathological H. influenzae infections, and in particular, vaccines for use in children and other individuals who respond poorly to capsular-based vaccines. DNA segments encoding these proteins and anti- HxuB and HxuC antibodies will also be of in various screening, diagnostic and therapeutic applications.

Growing community of inventors

Mesquite, TX, United States of America

Leslie D Cope