Pharmacia & Upjohn Company

Pharmacia Corporation

Leslie C Hawley

Satish Kumar Singh

Paramita Bandyopadhyay

Rebanta Bandyopadhyay

Sandra M Sims

Lisa A Adams

Praveen Tyle

Syed Hasan

Pamela J Secreast

Vincent E McCurdy

There is provided a pharmaceutical preservative free composition suitable for topical administration to an eye, the composition comprising (a) an oxazolidinone antimicrobial drug, for example linezolid, in a therapeutically or prophylactically effective drug concentration that is above the practical limit of solubility of the drug in a substantially isotonic aqueous solution at a physiologically compatible pH, and (b) a pharmaceutically acceptable cyclodextrin compound in a concentration sufficient to maintain the drug in solution at such a drug concentration. The composition is particularly useful for the treatment and/or prevention of eye infections due to gram positive bacteria.

Preservative free ophthalmic oxazolidinone antibiotic drug delivery systems

There is provided a pharmaceutical composition suitable for topical administration to an eye, the composition comprising as active agent at least one oxazolidinone antibacterial drug, for example linezolid, in a concentration effective for treatment and/or prophylaxis of a gram-positive bacterial infection of an eye, and at least one ophthalmically acceptable excipient ingredient that reduces a rate of removal of the composition from the eye by lacrimation such that the composition has an effective residence time in the eye of about 2 to about 24 hours. The composition is, for example, an in situ gellable solution, suspension or solution/suspension.

Topical antibiotic composition for treatment of eye infection

Growing community of inventors

Kalamazoo, MI, United States of America

Leslie C Hawley