The Rockefeller University

University of Pennsylvania

Columbia University

Duke University

Leslie B Vosshall

Andreas Keller

Richard Axel

Hiroaki Matsunami

Hanyi Zhuang

Michael W Young

Amita Sehgal

Qiuyi Chi

Michael P Myers

Jeffrey L Price

Julien Wen Hsieh

Hubert O Amrein

Disclosed are compositions and methods for measuring olfactory sensitivity, olfactory resolution, and combinations thereof. Such measurements can be made during a single test, or over consecutive tests, which may be performed during a single testing period, such as in a single day, or over a series of testing periods. The tests may be performed by a health care professional, or may be conveniently self-administered by the user.

Compositions and methods for a universal clinical test for olfactory dysfunction

The present invention relates to the characterization of odorant receptors. In particular, the present invention relates to the OR7D4 proteins and nucleic acids encoding OR7D4 proteins and cell systems for screening for modulators of OR7D4 receptors. The present invention further provides assays for the detection of OR7D4 polymorphisms and mutations associated with altered olfactory sensation states, as well as methods of screening for therapeutic agents, ligands, and modulators of OR7D4 receptors.

Compositions and methods for characterizing and regulating olfactory sensation

This invention provides an isolated nucleic acid molecule encoding an insect odorant receptor. This invention provides a nucleic acid molecule of at least 12 nucleotides capable of specifically hybridizing with the nucleic acid molecule encoding an insect odorant receptor. This invention also provides a purified, insect odorant receptor. This invention provides an antibody capable of specifically binding to an insect odorant receptor. This invention provides a method for identifying cDNA inserts encoding an insect odorant receptors. This invention provides a method of identifying a compound capable of specifically bind to an insect odorant receptor. This invention also provides a method of identifying a compound capable of activating the activity of an insect odorant receptor.

Genes encoding insect odorant receptors and uses thereof

The invention includes a nucleic acid encoding a nuclear localization protein which binds to, stabilizes and translocates to the nucleus a protein involved in circadian rhythms. Also included are the protein encoded by the nucleic acid, antibodies to the protein, and compositions and kits for the diagnosis and treatment of disorders related to the sleep-wake cycle.

Nuclear localization factor associated with circadian rhythms

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New York, NY, United States of America

Leslie B Vosshall