Purdue Research Foundation

Methodist Hospital of Indiana, Inc.

Other

Medtronic, Inc.

Med Institute Incorporated

Bioanalytical Systems, Inc.

Leslie A Geddes

Joe D Bourland

Stephen Francis Badylak

Neal E Fearnot

Arthur C Coffey

Charles F Babbs

Gary C Lantz

William A Cook

Willis A Tacker, Jr

Rebecca A Roeder

K Donald Shelbourne

Kirk Solon Foster

William E Schoenlein

Michael C Hiles

George P Graber

William John Havel

William D Voorhees, Iii

Matthew S Waninger

Tarek Elabbady

Jerry L Wessale

Robert G Matheny

Umesh H Patel

Darrell Orvin Wagner

Frederick J Shipko

Robert J Demeter

Candice B Kissinger

Joseph A Bougher

Reese S Terry

Willis A Tacker

John A Pearce

David S Grubbs

William D Vorhees, Iii

James Hong

Fred J Obermiller

Marvin H Hinds

Stephen J Clevenger

Claude B Harrington

Charles F Barbs

Anthony C Raghep

An auditory pulse monitor for noninvasively detecting the amplitude of arterial pulses on a beat-by-beat basis. A light-weight optical sensor including a light source and photodetector is adapted for application to the skin surface of a subject over a tissue bed containing an arterial supply. The photodetector generates an output signal proportional to the amplitude of an arterial pulse, and an electronic circuit connected to the photodetector generates a signal having a frequency proportional to the photodetector output signal level. A speaker or other audio indicator connected to the electronic circuit generates an audible tone indicating the amplitude of the arterial pulse. Another aspect of the invention is an improvement in automated or automatic external defibrillators (AEDs). An AED is disclosed which optically detects arterial pulses after delivering a defibrillation shock and signals the need for CPR if it detects inadequate cardiac pumping following successful defibrillation.

Apparatus and method for noninvasively detecting the quality of cardiac pumping

An optical noninvasive vital sign monitor comprising a reflectance-type optical sensor within a pressurizable capsule retained by a headband, the capsule having an optically transparent or translucent inner wall adapted for placement against a subject's forehead. The optical sensor is mounted on the inside surface of the pressurizable capsule's inner wall, which contacts the subject's forehead during use, and includes a light source and a photodetector aimed toward the inside surface of the inner capsule wall. One embodiment of the vital sign monitor includes optical oscillometric circuit means responsive to an output signal from the optical sensor for determining systolic pressure, mean pressure and diastolic pressure during a transition in capsule pressure between a pressure greater than normal systolic pressure and a pressure less than normal diastolic pressure.

Optical noninvasive vital sign monitor

An electrocardiography device and method that is able to obtain the electrocardiogram of a freely moving animal. The device and method utilizes at least two catheters to obtain the electrical signals from the heart of the animal being tested. The catheters are filled with an electrically-conductive, physiological solution and are used in combination with at least two test leads that are able to transfer the electrical signals from the animal to an ECG monitoring device. The device and method also allows for fluids to flow through the catheters to other devices such as a blood sampler controller and/or an infusion pump.

Device and method for electrocardiography on freely moving animals

An oscillometric, noninvasive blood pressure monitor comprising an inflatable cuff adapted for placement around a body member, a pump for cuff inflation, a pressure transducer connected to the cuff, means for detecting oscillations in arterial pressure occurring during a transition in cuff pressure between a pressure greater than normal systolic pressure and a pressure less than normal diastolic pressure, and a blood pressure measurement circuit which is capable of determining the maximum amplitude (A) of the oscillations, identifying mean cuff pressure (P) as the coincident value of the cuff-pressure signal from the pressure transducer, and determining systolic pressure as a function of both Aand P. In accordance with one aspect of the invention, the blood pressure monitor has an optical sensor including a light source and photodetector optically coupled to the body member proximate to the cuff. Oscillations in the output signal of the photodetector are detected, and the blood pressure measurement circuit determines the oscillation amplitude corresponding to systolic pressure (A) as a function of both Aand P.

Oscillometric noninvasive blood pressure monitor

A member-illuminating cuff for measurement of systolic, mean and diastolic pressure, oxygen saturation, pulse and respiratory rate in small body members, comprising a hinged cuff housing, one or more light sources mounted on a first section of the housing, a photodetector mounted on a second section of the housing, and a disposable, inflatable cuff adapted to fit within the cuff housing and around a body member placed therein.

Body-member-illuminating pressure cuff for use in optical noninvasive measurement of blood parameters

A controlled-power defibrillator and method of defibrillation for automatically compensating for changes in patient resistance during delivery of a defibrillation pulse. A switching power converter is connected between a storage capacitor and a pair of electrodes adapted for connection to a patient's body, either internally or externally. A closed-loop power control circuit is operatively connected to the power converter for control of the power delivered to the patient, the power control circuit generating a target voltage signal for the storage capacitor, the target voltage signal having a defined relationship with the waveform of the power desired to be delivered to the patient. The power control circuit monitors the actual voltage on the storage capacitor and adjusts the delivery of power to the patient as a function of the difference between desired and actual storage capacitor voltage. The power converter is adapted to capture energy from the discharge of an existing defibrillator and to convert captured energy from the existing defibrillator to a waveform different from that generated by the existing defibrillator.

Controlled-power defibrillator and method of defibrillation

A tissue graft construct and method for repairing the inner linings of damaged or diseased vertebrate vessels is described. The method comprises the steps of positioning a tissue graft construct within a blood vessel at a site in need of repair. The tissue graft construct comprises a stent ( ) covered with submucosal tissue ( ) wherein the stent ( ) is formed for receiving the distal end of a catheter ( ) having an inflatable balloon ( ).

Stent with reduced thrombogenicity

An easy-to-produce and mechanically strong tube of an implantable submucosal tissue has been developed which is manufactured in any desired length, wall thickness, or diameter. The construct produced by the method of the invention may be used as grafts for arteries, veins, ureters, urethras, shunts, or in any application where a compliant, tissue-compatible tube is needed. The manufacture of the submucosal tissue prosthesis generally involves wrapping a first sheet of submucosal tissue (,) and a second sheet of submucosal tissue (,) around a mandrel (,), wherein the first end (,) and the second opposite end (,) of the second sheet of submucosal tissue (,) are sutured together with sutures (,). The submucosal tissue is compressed and dried on the mandrel (,) before removing the construct by pulling on a first end (,) and a second end (,) of a water permeable tape to unwind the tape and thus release the construct for eventual use.

Tubular submucosal graft constructs

Artificial vascular valves

Myocardial graft constructs

A closed-loop, variable-frequency, vagal-stimulation apparatus for control of ventricular rate during atrial fibrillation. In one embodiment the apparatus includes a stimulator applied to the left vagus nerve and a controller programmed to automatically and continuously adjust the vagal stimulation frequency as a function of the difference between actual and desired ventricular excitation rates. In a second embodiment the apparatus includes a vagal nerve stimulator and a controller which automatically adjusts the vagal stimulation frequency as a function of the difference between ventricular excitation rate and arterial pulse rate in order to eliminate or minimize pulse deficit.

Method and apparatus using vagal stimulation for control of ventricular

A closed-loop variable frequency vagal stimulation apparatus for control of ventricular rate during atrial fibrillation. In one embodiment the apparatus includes a stimulator applied to the left vagus nerve and a proportional controller programmed to automatically and continuously adjust the vagal stimulation frequency proportionally as a function of the difference between actual and desired ventricular excitation rates. In a second embodiment the apparatus includes a vagal nerve stimulator and a controller which automatically adjusts the vagal stimulation frequency as a function of the difference between ventricular excitation rate and arterial pulse rate in order to eliminate or minimize pulse deficit.

Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.

Graft for promoting autogenous tissue growth

Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa, and basilar mucosa tissue delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.

Tendon or ligament graft for promoting autogenous tissue growth

Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa and basilar mucosa tissue delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.

Growing community of inventors

West Lafayette, IN, United States of America

Leslie A Geddes