Vaccinex, Inc.

Leslie A Croy

Ernest S Smith

Mark Paris

Maurice Zauderer

Renee A Kirk

Tracy Pandina

Angelica Moksa

Maria G M Scrivens

The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for antigen-specific immunoglobulin molecules, and antigen-specific fragments thereof. The invention also provides kits for producing, screening and selecting antigen-specific immunoglobulin molecules. Finally, the invention provides immunoglobulin molecules, and antigen-specific fragments thereof, produced by the methods provided herein.

Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus

Method for selecting polynucleotides encoding antigen-specific immunoglobulin subunits

Provided are monoclonal antibodies and antigen binding fragments thereof that specifically bind vascular endothelial growth factor (VEGF). The anti-VEGF monoclonal antibodies block VEGF binding to its receptors (e.g., VEGFR1 and/or VEGFR2) and prevent phosphorylation of VEGFR2 by VEGF. Also provided are methods of using the monoclonal anti-VEGF antibodies for treatment of disease, including cancer.

Anti-VEGF antibodies and uses thereof

The invention relates to antibodies which bind to tumor necrosis factor &#x3b1; (TNF&#x3b1;) and uses thereof, in particular in the diagnosis and treatment of autoimmune diseases, e.g. rheumatoid arthritis (RA). Specific human monoclonal antibodies which inhibit TNF&#x3b1;-mediated signalling pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human monoclonal antibodies which block the ability of TNF&#x3b1; to bind to its receptor, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating autoimmune diseases, e.g. rheumatoid arthritis (RA), using antibodies of the invention.

Selection of human TNF&#x3b1; specific antibodies

Growing community of inventors

Lakeville, NY, United States of America

Leslie A Croy