Vaccinex, Inc.

Leslie A Balch

Ernest S Smith

Renee A Kirk

Maurice Zauderer

Mark Paris

Pamela M Holland

Andrew Lake

Maria G M Scrivens

Angelica A Cornelison

Tracy Pandina

Shuying Shi

Loretta Mueller

Austin Dulak

Caroline Harvey

Maria Scrivens

Christopher Converse Wells

Sonia G Das

Angelika Moksa

This disclosure provides compositions and methods for expressing and displaying isolated integral membrane proteins (IMPs) or fragments thereof in a native conformation on poxvirus extracellular virions and methods for screening, selecting, and identifying antibodies or antibody-like molecules that bind to a target IMP of interest.

Integral membrane protein display on poxvirus extracellular enveloped virions

The present disclosure is directed to antibodies or antigen-binding portions thereof that specifically bind human CCR8, polynucleotides and vectors encoding the same, and pharmaceutical compositions comprising the same. Some aspects of the disclosure are directed to methods of treating a disease or condition comprising administering the anti-CCR8 antibody to a subject in need thereof.

Anti-CCR8 antibodies and uses thereof

The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for antigen-specific immunoglobulin molecules, and antigen-specific fragments thereof. The invention also provides kits for producing, screening and selecting antigen-specific immunoglobulin molecules. Finally, the invention provides immunoglobulin molecules, and antigen-specific fragments thereof, produced by the methods provided herein.

Method for selecting polynucleotides encoding antigen-specific immunoglobulin subunit

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Lakeville, NY, United States of America

Leslie A Balch