Galileo Pharmaceuticals, Inc.

Johnson & Johnson Consumer Companies, Inc.

Lesley A Brown

Guy M Miller

Sekhar S Boddupalli

Bing Wang

Stephen F Flaim

Ughetta Del Balzo

Wei Zhang

Jiangao Song

Peggy Beinlich

Darlene M Dreon

Stephen D Phinney

Jian Chen

Yong-Kang Zhang

Gail Walkinshaw

Sylvain Gilat

Steven Bobzin

Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods

The present invention provides non-alpha-tocopherol enriched tocopherol compositions and non-alpha-tocopherol metabolite enriched compositions for use in the reduction of inflammatory markers associated with inflammation such as C-reactive protein.

Tocopherol enriched compositions and amelioration of inflammatory symptoms

Non-alpha-tocopherol enriched tocopherol compositions and non-alpha metabolite enriched compositions are disclosed for use in the reduction of the inflammatory marker IL-6.

Tocopherol enriched compositions for reducing IL6 levels

The present invention provides method for the treatment of a symptom of neuronal damage associated with cerebral ischemia comprising administering gamma-, beta-, or delta-tocopherol enriched tocopherol compositions.

Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols

Furanone derivatives and the pharmaceutically acceptable salts thereof have cytoprotective activity and protective activity for neuroinflammation, and neurodegenerative disorders; they are useful in the treatment of stroke, cerebral ischemia, myocardial infarction, myocardial ischemia, chronic heart failure, inflammation and other oxidative stress-related conditions, as well as Alzheimer's disease and senile dementia; they are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

Furanone derivatives

Growing community of inventors

East Palo Alto, CA, United States of America

Lesley A Brown