Excaliard Pharmaceuticals, Inc.

Bodyaesthetic Research Center, Inc.

Leroy Young

Nicholas M Dean

Niall O'Donnell

Gregory E Hardee

J Gordon Foulkes

Lincoln Krochmal

Mark Jewell

This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.

Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (CTGF)

A surgical incision marking template for marking a breast with an intended incision pattern prior to surgery comprises a pliable structural portion with a guide portion. The guide portion is substantially shaped and/or shapeable into a 'keyhole' pattern. The keyhole pattern corresponds to the incision pattern generally utilized for the vertical short scar and the inferior pedicle techniques for breast reduction or mastopexy surgery and comprises a generally circular pattern and a generally linear pattern, with the generally linear pattern extending downward from the generally circular pattern when the template is placed on a standing patient. The pliable nature of the structural portion not only allows the shape of the guide portion to be altered but also allows the structural portion to conform to the curvature and shape of the breast. Methods of use for the template to mark the breast are also disclosed.

Marker template for breast reduction surgery

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Wildwood, MO, United States of America

Leroy Young