Vestar, Inc.

Ethicon, Gmbh

LeRoy L Richer

Shalaby Wahba Shalaby

Gere S DiZerega

Paul G Schmidt

Warren D Sheffield

Douglas B Johns

Joseph A Uliana

Paula J Konigsberg

Delivery vehicle formulations comprise active agents encapsulated within liposomal vesicles to which are attached protein hormones (ligands) such as interleukin-2. The ligands are capable of showing affinity for specific cell receptors resulting in delivery of the encapsulated active agent to target cells, enabling delivery of active agents to particular cell populations in the treatment of conditions such as immune system disorders.

Liposome targeting using receptor specific ligands

Postsurgical adhesion formation is inhibited by the topical administration to the site of surgical trauma of a non-steroidal anti-inflammatory drug, preferably ibuprofen, suprofen, or tolmetin.

Method for inhibiting post-surgical adhesion formation by the topical

Liposomal multilamellar vesicles suitable for sustained delivery of therapeutic agents to the peritoneal cavity and a method for their formulation are described. The liposomal multilamellar vesicles comprise a phosphatidylcholine having fatty acid side chains of from 12 to 24 carbons in length and have a size of from about 1 micron to about 15 microns in diameter.

Liposomal vesicles for intraperitoneal administration of therapeutic

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San Gabriel, CA, United States of America

LeRoy L Richer