University of Michigan

Other

Chimerix, Inc.

University of Utah Research Foundation

The United States of America As Represented by the Department of Health

Smithkline Beecham Corporation

Wake Forest University

Glaxo Wellcome Inc.

Burroughs Wellcome Co.

The United States of America As Represented by the Secretary of Health

Leroy B Townsend

John Charles Drach

Roy Wendell Ware

Ernest Randall Lanier, Jr

Andrew Louis McIver

Dean Wallace Selleseth

Bradley David Robertson

Phiroze Behram Sethna

Ramamurty V S Changalvala

John Henry Bougher, Iii

Robert A Earl

Susan Mary Daluge

Louis S Kucera

Aaron Leigh Downey

Stanley Dawes Chamberlain

George Andrew Freeman

Michael Tolar Martin

Oscar L Acevedo

George Walter Koszalka

Marc W Andersen

David Norman Deaton

Jeffrey H Tidwell

George A Freeman

Charles Shipman, Jr

Frank Leslie Boyd, Jr

Dean S Wise

Steven J Manning

Arthur F Lewis

Linda W Roti Roti

T Craig Thurber

Dean Sylvester Wise

Joseph H Chan

John G Drach

Jeffrey S Pudlo

Steven H Krawczyk

Siya Ram

Thomas E Renau

Steven S Good

John Henry Iii Bougher

The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rand A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.

Pyrrolopyrimidine nucleosides and analogs thereof

The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rand A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II. 

The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.

Indole antiviral compositions and methods

Benzimidazole derivatives useful for treating or preventing viral infections such as those caused by herpes viruses or in the treatment of restenosis following surgical techniques. Methods of preparing these benzimidazole derivatives and pharmaceutical compositions containing them are described.

Benzimidazole derivatives

Lyxofuranosyl benzimidazoles as antiviral agents

Benzimidazole derivatives for the treatment of viral infections

Triciribine and analogs are effective antiviral agents.

Triciribine and analogs as antiviral drugs

Pyrrolo&lsqb;2,3-d&rsqb; pyrimidines as antiviral agents

This invention pertains to nucleoside analogs that have antiviral activity and improved metabolic stability, compositions comprising them, and methods of antiviral treatment employing them. More particularly, this invention pertains to imidazo&lsqb;1,2-a&rsqb;pyridine C-nucleosides, as exemplified by compounds such as imidazo&lsqb;l,2-a&rsqb;pyridine C5-nucleosides and imidazo&lsqb;1,2-a&rsqb;pyridine C3-nucleosides, and may be represented by formula (I), wherein exactly one of Q,and Q,is a sugar-like moiety; exactly one of Q,and Q,is &mdash;H; and Q,, Q,, Q,and Q,are independently imidazo&lsqb;1,2-a&rsqb;pyridine substituents, such as &mdash;H, &mdash;F, &mdash;Cl, &mdash;Br and &mdash;I.

Imidazo&lsqb;1,2-a&rsqb;pyridine C-nucleosides as antiviral agents

Growing community of inventors

Ann Arbor, MI, United States of America

Leroy B Townsend