Sorin Biomedica Cardio S.p.a.

Dideco S.p.a.

Other

Innosense, S.r.l.

Leopoldo Della Ciana

Giuseppe Caputo

Stefano Rinaldi

Arnaldo Giannetti

Andrea Grignani

Elena Comoglio

Raffaele Castelli

Maria Curcio

Anilla Massaglia

Giuliana Bernacca

Mariacristina Cassullo

Giampero Porro

Silvio Sacco

Silvia Pascale

Symmetric, monofunctionalised polymethine dyes labelling reagents

Process and method for the preparation of asymmetric monofunctionalized indocyanine labelling reagents and obtained compounds

A device for determining the concentration of heparin in a fluid sample comprising: a container for holding the fluid sample; a container for holding the dye solution; a mixer for mixing the fluid sample and the dye solution; an illumination source for illuminating a mixture comprising the fluid sample and the dye solution with electromagnetic radiation having a substantially continuous range of wavelengths in the visible range; a detector for detecting the absorption spectrum of the mixture within the substantially continuous range of wavelengths; a recorder for recording the absorption spectrum of the mixture within the substantially continuous range of wavelengths; and a calculator for calculating a spectral parameter.

Method and device for determining the concentration of heparin in a sample of fluid

A method for determining the concentration of heparin in a fluid sample comprising: (a) providing a fluid sample containing heparin; (b) adding to the fluid sample a solution of a dye to form a mixture of sample and dye, wherein the dye interacts with the heparin in the sample so that the absorption spectrum of the mixture of sample and dye in the visible range varies as a result of the interaction in a manner quantitatively dependent on the heparin concentration; (c) determining the absorption spectrum in the visible range of the mixture of sample and dye; and (d) calculating a spectral parameter representative of both the reduction in the absorption of the free dye in solution and the increase in the absorption of the dye-heparin complex, the value of the spectral parameter being indicative of the concentration of heparin present in the fluid sample, in order to determine the concentration of heparin present in the fluid sample. The relationship between the value of the spectral parameter and the concentration of the heparin present in the fluid sample has been previously determined by determining the absorption spectra, in the visible range, of a composition comprising the fluid and the dye, in the absence of heparin and in the presence of a plurality of concentrations of heparin, and calculating the relationship between the value of the spectral parameter and the concentration of heparin. A device for performing this method is also provided.

Fluorescent cyanine labels containing a sulfamido linker arm

The apparatus comprises an implantation device having a body, the surface of which has at least a portion coated with a receptor, and a preparation containing a ligand formed from the combination of an active principle with a substance capable of binding to the receptor. This preparation may be brought into contact when desired with the implantation device which is, for example, a stent.

Implantation device and a kit including the device

Sulfo benz[E]indocyanine flourescent dyes

A method for reducing foam in a blood substance comprising contacting at least a portion of the blood substance with a contact-generating substrate which comprises an antifoaming agent, wherein the antifoaming agent comprises a triglyceride of one or more saturated or unsaturated C.sub.14 -C.sub.24 fatty acids or a mixture of triglycerides having one or more saturated or unsaturated C.sub.14 -C.sub.24 fatty acids, wherein the triglyceride or mixture of triglycerides has a hydrophilic-lipophilic balance of from 5 to 10.

Method for reducing foam in a blood substance and antifoaming agents

A method of preparing biological implantation material fixed by means of aldehydes, in which the excess aldehyde is bound by treatment with an aminocarboxylic acid and the acid is selected from compounds of the general formula: ##STR1## in which n is 1 or 2 and X is a sulpho- (--SO.sub.3 H) or phosphono- (--PO.sub.3 H) group, and mixtures of such compounds.

Method of preparing biological implantation material

Growing community of inventors

Ivrea, Italy

Leopoldo Della Ciana