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Sociedad Espanola De Especialidades Terepeuticas, S.a.

Sociedad Espanola De Especialidades Farmacotera Peuticas

Leonida Bruseghini

Xavier D Cirera

Romeo R Andreoli

Pedro P Lloveras

Silvano Casadio

Jose P Irurre

Jorge P Iniesta

Jose Miguel Ribalta

Jose P Irrure

Jorge D Adsara

Jose M Ribalta

The dihydrodibenzocycloheptyliden-ethylpiperazine derivative has the formula: ##STR1## wherein R represents a substituent selected from the group consisting of --CH.dbd.CH.sub.2 ; --CO.sub.2 C.sub.2 H.sub.5 ; --CH.dbd.CH--CO.sub.2 CH.sub.3 ; ##STR2## and

Vasodilatory dihydrodibenzocycloheptyliden-ethylpiperazine derivatives

Dihydrodibenzocycloheptyliden-ethylene derivatives of the general formula: ##STR1## in which, R.sub.1 represents an alkyl group having from 1 to 4 carbon atoms;

Antiulcer dihydrodibenzocycloheptyliden-ethylamine derivatives and

A dihydrodibenzocycloheptyliden-ethyl-piperazine derivative of the general formula: ##STR1## in which, R=--CH.dbd.CH.sub.2 ; --CH.sub.2 OH; --COOH; --CO.sub.2 C.sub.2 H.sub.5 ; --CH.dbd.CH--CO.sub.2 CH.sub.3 ; --CH.dbd.CH--CO.sub.2 CH.sub.3, --C.sub.6 H.sub.5, ##STR2## or pharmaceutically acceptable salts thereof, are disclosed. The compounds of the invention are useful in pharmaceutical compositions for the treatment of pathologies responsive to vasodilatory agents.

Vasodilatory dihydrodibenzocycloheptyliden-ethyl piperazine derivatives

A new dioxolanic amine is disclosed, with pharmacological activity of the following structural formula I: ##STR1## as well as its pharmaceutically acceptable salts, possessing intense vasodilatory, anti-angina and anti-arrhythmic activity, accompanied by a low toxicity; its method of preparation; pharmaceutical compositions containing the said compounds; and the treatment and prevention various pathological conditions with the use of said compositions. Also disclosed are new dioxolanic compound of the following structural formula II: ##STR2## which is an intermediate compound in the preparation of the formula I compound; and its method of preparation.

Dioxolanic amine with pharmacological activity, its method of

S-(3-methyl-2-butenyl)cysteine ##STR1## or a pharmaceutically acceptable salt thereof. The compound is an expectorant and can be applied in the form of capsules or dragees, solutions, syrups or suppositories.

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Barcelona, Spain

Leonida Bruseghini