Ajinomoto Co., Ltd.

Leonid Romanovich Ptitsyn

Tatyana Abramovna Yampolskaya

Mikhail Markovich Gusyatiner

Yury Ivanovich Kozlov

Irina Borisovna Altman

Tatyana Viktorovna Leonova

Yulia Georgievna Rostova

Sergey Vasil'evich Smirnov

Veronika Aleksandrovna Kotliarova

Natalia Viktorovna Stoynova

Ekaterina Alekseevna Savrasova

Natalia Sergeevna Eremina

Natalia Nikolaevna Samsonova

Valery Zavenovich Akhverdian

Valeriy Zavenovich Akhverdian

Vladimir Yurievich Ermishev

Anna Eugenievna Novikova

Olga Nikolaevna Mokhova

The present invention provides a method for producing L-amino acid using a bacterium belonging to the family Enterobacteriaceae, particularly a motile bacterium belonging to the genusor, wherein the bacterium has been modified so that expression of at least one gene of the flagella formation and motility cascade is enhanced.

Method for producing an L-amino acid using a bacterium of the family Enterobacteriaceae having enhanced expression of the flagella formation and motility cascade genes

The present invention provides a method for producing an L-amino acid from ethanol using a bacterium of thefamily, wherein the bacterium has been modified to enhance the expression of the ydbK gene.

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L-arginine, citrulline and pyrimidine derivatives including orotic acid, uridine, uridine 5'-monophosphate (UMP), cytidine and cytidine 5&#x2032;-monophosphate (CMP) are produced using a bacterium belonging to the genusharboring a mutant carbamoylphosphate synthetase in which the amino acid sequence corresponding to positions from 947 to 951 in a wild type carbamoylphosphate synthetase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 9, and feedback inhibition by uridine 5&#x2032;-monophosphate in the bacterium is desensitized.

Mutant carbamoylphosphate synthetase and method for producing compounds derived from carbamoylphosphate

L-arginine is produced using a bacterium belonging to the genusharboring a mutant N-acetylglutamate synthase in which the amino acid sequence corresponding to positions from 15 to 19 in a wild type N-acetylglutamate synthase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 4, and feedback inhibition by L-arginine is desensitized.

Arginine can be efficiently produced by cultivatingwhich has an ability to produce arginine and an ability to utilize acetate in a culture medium to produce and accumulate arginine in the medium, and collecting arginine from the medium.

L-arginine producing Escherichia coli and method of producing L-arginine

L-arginine is produced using a bacterium belonging to the genus Escherichia harboring a mutant N-acetylglutamate synthase in which the amino acid sequence corresponding to positions from 15 to 19 in a wild type N-acetylglutamate synthase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 4, and feedback inhibition by L-arginine is desensitized.

Mutant N-acetylglutamate synthase and method for L-arginine production

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Moscow, Russia

Leonid Romanovich Ptitsyn