Gritstone Bio, Inc.

Seattle Project Corp.

Leonid Gitlin

Ciaran Daniel Scallan

Karin Jooss

Amy Rachel Rappaport

Wade Blair

Roman Yelensky

James Xin Sun

Brendan Bulik-Sullivan

Monica Lane

Christine Denise Palmer

Adnan Derti

Gijsbert Grotenbreg

Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.

Alphavirus neoantigen vectors

Compositions include modified adenoviruses. Nucleotides, cells, and methods associated with the compositions, including their use as vaccines. Viral vectors using a TET promoter system and methods of producing viruses having the same.

Modified adenoviruses

Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of KRAS neoepitope-encoding sequences and/or lacking immunodominant epitopes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.

Multiepitope vaccine cassettes

Alphavirus antigen vectors

Growing community of inventors

Foster City, CA, United States of America

Leonid Gitlin