Alfa Wassermann S.p.a.

Leone G Rotini

Egidio Marchi

Manlio Cristofori

Maria Rosaria Pantaleo

Antonella Ferrieri

Patrizio Ferrari

Lorenzo Morelli

Claudio Giuseppe Viscomi

Salvatore Mardente

The disclosure refers to biologically pure cultures of two strains ofnamed W11 and W11and deposited at the Belgian Coordinated Collections of Microorganisms (BCCM) that has registered them under the accession numbers LMG P-21586 and LMG P-21587. They are used as probiotics within preparations of pharmaceutical or alimentary products to help the gastrointestinal health and to prevent and treat the intestinal pathologies.

Bifidobacteria and preparations containing them

Pharmaceutical compositions for intranasal administration containing in a spray dosing feeder calcitonin dissolved in a substantially physiological solution of sodium chloride adjusted to a pH between 3.5 and 4.5 with citrate buffer and hydrochloric acid without any preservative are the object of the present invention.

Pharmaceutical compositions containing calcitonin in a spray dosing

Programmed release tablets, to be administered by oral route, containing from 500 to 1,200 mg of naproxen, made by mixtures of an immediate release granulate dry compacted containing from 5% to 28% of naproxen, of a controlled release granulate dry compacted containing from 72% to 95% of naproxen and of a disintegrating agent. A portion of naproxen is released in a short time, so that the drug can quickly develop its therapeutic action reaching the necessary hematic levels, while the remaining portion is released in a longer interval of time, so as to allow the therapeutic coverage until the subsequent administration. The therapeutic coverage is effective for a period of 24 hours; thus the tablets object of the present invention are suitable for a once a day administration.

Programmed release tablets containing naproxen

The antibiotic known by the name rifaximin (INN) is active orally in the treatment of gastric dyspepsia caused by bacteria known as Helicobacter pylori. Rifaximin may be administered in any oral pharmaceutical form, particularly tablets, capsules, sugar coated tablets, granules and syrups containing from 200 to 2000 mg of active principle, at a daily dosage of between 400 and 2000 mg.

Use of rifaximin and pharmaceutical formulations containing it in the

Pharmaceutical compositions for oral use, preferably selected from capsules, tablets or sugar coated tablets, coated by an enterosoluble gastroresistant film, containing a lyophilizate consisting of therapeutically effective amounts of a glycosaminoglycan, a thickening substance and surfactants, and process for obtaining them. The compositions make possible the absorption of the orally administered glycosaminoglycans in the duodenum and in the intestine and the consequent performance of their anticoagulant, fibrinolytic, antithrombotic, antiatherosclerotic and antihyperlipoproteinemic properties.

Pharmaceutical compositions containing orally absorbable

New galenic formulations with programmed release, to be administered by the oral route, containing as the active ingredient a drug selected from the non steroidal antiinflammatory, bronchodilator, vasodilator, cardiovascular and muscle relaxant drugs.

Galenic formulations with programmed release

A galenic formulations are disclosed with programmed release, to be administered orally containing as the active ingredient a compound having antiphlogistic, analgesic and antipyretic activity like, for instance, an arylacetic or an arylpropionic acid, and pharmaceutically acceptable salts thereof. In these new formulations, a portion of the active ingredient is released in a short time, so that the drug can quickly develop its therapeutic action and reach the necessary hematic levels, while the remaining portion of the active constituent is released in a longer interval of time so as to allow therapeutic coverage until subsequent administration. The therapeutic coverage can even last twenty-four hours. Thus, the new galenic formulations object of the present invention are suitable for administration one a day.

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Bologna, Italy

Leone G Rotini