Danisco US Inc.

Leonardus P M Van Marrewijk

David Aaron Estell

Ayrookaran J Poulose

Andrew Shaw

Brian E Jones

Marc Kolkman

Wolfgang Aehle

Hiroshi Oh

Chris Leeflang

Ronaldus W J Hommes

Wilhelmus A H Van Der Kley

The present invention provides novel Micrococcineae spp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA encoding the proteases, host cells transformed with the vector DNA, and enzymes produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising these serine protease variants. In particularly preferred embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These variant proteases also find use in numerous applications.

Multiple mutation variants of serine protease

The present invention provides novelspp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA encoding the proteases, host cells transformed with the vector DNA, and enzymes produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising these serine protease variants. In particularly preferred embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These variant proteases also find use in numerous applications.

Cellulomonas 69B4 serine protease variants

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Leiden, Netherlands

Leonardus P M Van Marrewijk